Applicability of a carbon paste electrode modified with manganese ferrite nanoparticles (MnFe2O4NPs) in simultaneous measurement of uric acid and dopamine

Considering the importance of DA (dopamine) and UA (uric acid) in the physiological process of the human body, the dosage controlling of them in the biofluids is crucial to monitor human health. Since the oxidation peaks of the DA and UA have an overlap on the bare electrode surface, the manganese ferrite nanoparticles (MnFe2O4 NPs) as the simple and cost-effective modifier can improve the electrochemical properties of the sensing interface in their simultaneous detection. Accordingly, a carbon paste electrode modified with the MnFe2O4 NPs (CPE/MnFe2O4 NPs) as the electrochemical sensor has been constructed. The embedded platform not only improved the electron transfer by increasing the surface area but also presented well-separated electro-oxidation peaks of the DA and UA with a higher current in the simultaneous detection of them. Applicability of the sensor was monitored in various concentrations of two analytes under two linear ranges of 1-50 mu M for DA and 1-70 mu M for UA with a limit of detection (LOD) of 0.45 mu M and 0.19 mu M, respectively. The sensor reliability in the presence of some common interferences confirmed selective measuring of the analytes. The satisfactory analysis results presented the sensor feasibility in the complex matrixes of the real samples, including human urine and blood serum, for the simultaneous detection of the analytes. These findings reveal the applicability of the MnFe2O4 NPs as a promising beneficial platform that may be a paradigm in other electrocatalysis fields.

Automated summary

The use of manganese ferrite nanoparticles as a modifier in an electrochemical sensor significantly improved the detection of dopamine and uric acid in biofluids, showing promise for simultaneous monitoring and selective measurement. The sensor demonstrated reliability in the presence of common interferences and feasibility in detecting the analytes in complex samples such as human urine and blood serum. These findings suggest the potential of MnFe2O4 NPs as a beneficial platform in electrocatalysis fields.