期刊
MATERIALS TODAY COMMUNICATIONS
卷 28, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.mtcomm.2021.102615
关键词
Chitosan; Flexible patch; Mechanical properties; Bone tissue engineering
资金
- CONACYT Mexico [A1-S-9557]
The study examined the properties of chitosan-hydroxyapatite-multiwall carbon nanotube films at various concentrations and found that certain combinations showed superior mechanical properties, conductivity, and biocompatibility, making them suitable for the development of a flexible patch for bone tissue engineering.
Herein we study the structure, mechanical, electrical properties of chitosan-hydroxyapatite-multiwall carbon nanotubes (CS-HAp-MWCNT) films in a wide range of concentrations and their biocompatibility with human osteoblasts to develop a biocompatible flexible patch. Properties of nanocomposites are assessed by SEM, FTIR, mechanical, and impedance measurements. It was shown that all properties strongly depend upon the agglomeration of fillers due to particle-particle interactions and the chitosan matrix. Nanocomposite films with 5 wt% of HAp nanoparticles and 0.5 wt% of MWCNT exhibit superior mechanical properties and a conductivity that compares well with human bone conductivity, and good biocompatibility with human osteoblasts. Our results suggest the high potential application of the proposed nanocomposites for the development of a flexible patch for bone tissue engineering.
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