Thyroid Nodule Characterization: How to Assess the Malignancy Risk. Update of the Literature

Ultrasound (US) is the first imaging modality for thyroid parenchyma evaluation. In the last decades, the role of ultrasound has been improved with the introduction of new US software, such as contrast-enhanced ultrasound (CEUS) and US-elastography (USE). USE is nowadays recognized as an essential part of the multiparametric ultrasound (MPUS) examination, in particular for the indeterminate thyroid nodule with possible fine-needle aspiration cytology (FNAC) number reduction; even if further and larger studies are needed to validate it. More controversial is the role of CEUS in thyroid evaluation, due to its high variability in sensitivity and specificity. Semi-automatic US systems based on the computer-aided diagnosis (CAD) system are producing interesting results, especially as an aid to less experienced operators. New knowledge on the molecular mechanisms involved in thyroid cancer is allowing practitioners to identify new genomic thyroid markers that could reduce the number of diagnostic thyroidectomies. We have therefore drawn up an updated representation of the current evidence in the literature for thyroid nodule multiparametric ultrasound (MPUS) evaluation with particular regard to USE, the US CAD system and CEUS.

Automated summary

Ultrasound is the primary imaging modality for evaluating thyroid parenchyma, with new software like CEUS and USE enhancing its role. While USE is now seen as an integral part of MPUS examination for thyroid nodules, the role of CEUS remains controversial due to variability. The advancement in molecular mechanisms allows for the identification of new genomic thyroid markers that could potentially reduce unnecessary thyroidectomies.