期刊
DIAGNOSTICS
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/diagnostics11091668
关键词
COPD; asthma; biomarker treatment; response
资金
- Danish Regions Medical Fund [5894/16]
- Danish Council for Independent Research [6110-00268B]
- Herlev and Gentofte Hospital, University of Copenhagen
Asthma and COPD, two common chronic diseases worldwide, have heterogeneous and complex characteristics with different responses to treatment, despite their similarities in pathophysiology and immunology. Systematic assessment of diagnosis and identification of biomarkers are essential for clinical management. Advances in understanding asthma and COPD, particularly related to eosinophilia as a treatable trait, have led to targeted treatments and improved outcomes.
Chronic obstructive pulmonary disease (COPD) and asthma are two of the most common chronic diseases worldwide. Both diseases are heterogenous and complex, and despite their similarities, they differ in terms of pathophysiological and immunological mechanisms. Mounting evidence supports the presence of several phenotypes with various responses to treatment. A systematic and thorough assessment concerning the diagnosis of both asthma and COPD is crucial to the clinical management of the disease. The identification of different biomarkers can facilitate targeted treatment and monitoring. Thanks to the presence of numerous immunological studies, our understanding of asthma phenotypes and mechanisms of disease has increased markedly in the last decade, and several treatments with monoclonal antibodies are available. There are compelling data that link eosinophilia with an increased risk of COPD exacerbations but a greater treatment response and lower all-cause mortality. Eosinophilia can be considered as a treatable trait, and the initiation of inhaled corticosteroid in COPD patients with eosinophilia is supported in many studies. In spite of advances in our understanding of both asthma and COPD in terms pathophysiology, disease mechanisms, biomarkers, and response to treatment, many uncertainties in the management of obstructive airways exist.
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