期刊
DIAGNOSTICS
卷 11, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/diagnostics11061082
关键词
circadian rhythms; OSA; biomarkers; genes; metabolites
资金
- CCHMC Procter Scholar Award
- National Institute of Health grant [5K08HL148551-02]
- American Society of Pediatric Otolaryngology (ASPO) of the Combined Otolaryngology Research Effort (CORE)
Obstructive sleep apnea can disrupt the molecular clock and impact various biological rhythms, potentially worsening cardiovascular or cognitive outcomes. Understanding circadian biology in the context of OSA could be crucial for improving diagnosis and treatment methods.
Obstructive sleep apnea (OSA) is a complex process that can lead to the dysregulation of the molecular clock, as well as 24 h rhythms of sleep and wake, blood pressure, and other associated biological processes. Previous work has demonstrated crosstalk between the circadian clock and hypoxia-responsive pathways. However, even in the absence of OSA, disrupted clocks can exacerbate OSA-associated outcomes (e.g., cardiovascular or cognitive outcomes). As we expand our understanding of circadian biology in the setting of OSA, this information could play a significant role in the diagnosis and treatment of OSA. Here, we summarize the pre-existing knowledge of circadian biology in patients with OSA and examine the utility of circadian biomarkers as alternative clinical tools.
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