期刊
GLYCOBIOLOGY
卷 26, 期 9, 页码 926-939出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/glycob/cww023
关键词
endoplasmic reticulum; glycosyltransferase; Golgi apparatus; N-glycan processing; N-glycosylation
资金
- Austria Science Fund (FWF) [P23906-B20]
- Austrian Science Fund (FWF) [P23906] Funding Source: Austrian Science Fund (FWF)
- Austrian Science Fund (FWF) [P 23906] Funding Source: researchfish
Protein glycosylation is an essential co- and post-translational modification of secretory and membrane proteins in all eukaryotes. The initial steps of N-glycosylation and N-glycan processing are highly conserved between plants, mammals and yeast. In contrast, late N-glycan maturation steps in the Golgi differ significantly in plants giving rise to complex N-glycans with beta 1,2-linked xylose, core alpha 1,3-linked fucose and Lewis A-type structures. While the essential role of N-glycan modifications on distinct mammalian glycoproteins is already well documented, we have only begun to decipher the biological function of this ubiquitous protein modification in different plant species. In this review, I focus on the biosynthesis and function of different protein N-linked glycans in plants. Special emphasis is given on glycan-mediated quality control processes in the ER and on the biological role of characteristic complex N-glycan structures.
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