期刊
ACS OMEGA
卷 6, 期 38, 页码 24473-24483出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.1c02855
关键词
-
资金
- Department of Chemistry at National Institute of Technology, Calicut
- National Institute of Technology, Calicut
Metal ions play a crucial role in environmental and biological applications, with a focus on detecting specific ions at minute levels. Benzothiazole-based chemosensors have been designed and synthesized for highly selective and sensitive detection of biologically important metal ions like Zn2+, Cu2+, and Ni2+. The sensors exhibit ratiometric and colorimetric responses to the target ions, making them valuable tools for bioimaging and environmental monitoring.
Metal ions play a very important role in environmental as well as biological fields. The detection of specific metal ions at a minute level caught much attention, and hence, several probes are available in the literature. Even though benzothiazole-based molecules have a special place in the medicinal field, only very few chemosensors are reported based on this moiety. The current work describes the design and synthesis of the benzothiazole-based chemosensor for a highly selective and sensitive detection of biologically important metal ions such as Zn2+, Cu2+, and Ni2+. The sensing studies of compound-1 showed a ratiometric as well as colorimetric response toward Zn2+, Cu2+, and Ni2+ ions and color changes from colorless to yellow and is found to be insensitive toward various metal ions (Cd2+, Cr3+, Mn2+, Pb2+, Ba2+, Al3+, Ca2+, Fe2+, Fe3+, Mg2+, K+, and Na+). Further, compound-1 exhibited ratiometric as well as turn-on-enhanced fluorescence response toward Zn2+ ions and turn off response for Cu2+ and Ni2+ ions. The Job plots revealed that the binding stoichiometry of compound-1 and metal ions is 2:1. The detection limits were found to be 0.25 ppm for Zn2+, while it was 0.30 ppm and 0.34 ppm for Ni2+ and Cu2+, respectively. In addition, density functional theory results strongly support the colorimetric response of metals, and the reversibility studies suggested that compound-1 can be used as a powerful chemosensor for the detection of Zn2+, Cu2+, and Ni2+ ions. The bioimaging data illustrated that compound-1 is a very effective ratiometric sensor for Zn2+ ions in live cells.
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