期刊
PLANTS-BASEL
卷 10, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/plants10061169
关键词
Salvia leucantha; essential oil; enantiomer distribution; GC-MS; GC-FID; BuChE inhibitory activity
资金
- Universidad Tecnica Particular de Loja (UTPL)
The essential oil of Salvia leucantha Cav. from Ecuador was analyzed by GC-MS and GC-FID, revealing major compounds such as sesquiterpenes and monoterpenoid. The oil demonstrated inhibitory activity against Butyrylcholinesterase in vitro, with potential for pharmaceutical use.
The essential oil (EO) of Salvia leucantha Cav. was isolated by steam distillation of the aerial parts collected in the South of Ecuador. Its physical properties were evaluated and the chemical composition of the oil was determined by GC-MS and GC-FID analyses using two chromatographic columns, DB-5ms and HP-INNOWax. Six major compounds were identified, namely, the sesquiterpenes 6.9-guaiadiene (19.14%), (E)-caryophyllene (16.80%), germacrene D (10.22%), (E)-beta-farnesene (10.00%), and bicyclogermacrene (7.52%), and the monoterpenoid bornyl acetate (14.74%). Furthermore, four pairs of enantiomers were determined by enantioselective GC-MS of the essential oil. (-)-germacrene D and (+)-alpha-pinene showed the highest enantiomeric excess (ee%). In an in vitro assay, the essential oil demonstrated an interesting inhibitory activity of the enzyme butyrylcholinesterase (BuChE), with an IC50 = 32.60 mu g/mL, which is the highest determined for a Salvia species. In contrast, the oil was weakly active against acetylcholinesterase (AChE) with an IC50 > 250 mu g/mL.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据