4.5 Article

Neurosensory Rehabilitation and Olfactory Network Recovery in Covid-19-related Olfactory Dysfunction

期刊

BRAIN SCIENCES
卷 11, 期 6, 页码 -

出版社

MDPI
DOI: 10.3390/brainsci11060686

关键词

COVID-19; olfactory dysfunction; vitamin A; smell training; resting-state fMRI

资金

  1. Shaw Foundation Hong Kong
  2. Jessie & George Ho Charitable Foundation
  3. Perfect Shape Medical Limited
  4. Respiratory Viral Research Foundation
  5. Hui Ming, Hui Hoy and Chow Sin Lan Charity Fund Limited
  6. Sanming Project of Medicine in Shenzhen, China [SZSM201911014]
  7. High Level-Hospital Program, Health Commission of Guangdong Province, China
  8. Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Diseases and Research Capability on Antimicrobial Resistance for the Department of Health of the Hong Kong Special Administrative Region Government
  9. Theme-Based Research Scheme of the Research Grants Council of the Hong Kong Special Administrative Region Government, China [T11/707/15]

向作者/读者索取更多资源

The study found that non-conductive olfactory dysfunction is an important extra-pulmonary manifestation of COVID-19, and olfactory treatment (OT) combining vitamin A and smell training can improve olfactory function in patients.
Non-conductive olfactory dysfunction (OD) is an important extra-pulmonary manifestation of coronavirus disease 2019 (COVID-19). Olfactory bulb (OB) volume loss and olfactory network functional connectivity (FC) defects were identified in two patients suffering from prolonged COVID-19-related OD. One patient received olfactory treatment (OT) by the combination of oral vitamin A and smell training via the novel electronic portable aromatic rehabilitation (EPAR) diffusers. After four-weeks of OT, clinical recuperation of smell was correlated with interval increase of bilateral OB volumes [right: 22.5 mm(3) to 49.5 mm(3) (120%), left: 37.5 mm(3) to 42 mm(3) (12%)] and improvement of mean olfactory FC [0.09 to 0.15 (66.6%)].

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