Myasthenia Gravis-An Analysis of Multimodal Evoked Potentials

Introduction: The aim of this study is a comprehensive analysis of the parameters of exogenous evoked potentials (visual, brainstem auditory, and somatosensory) in patients with myasthenia gravis (MG), a prototype of both neuromuscular junction disease and autoimmune disease. The study also seeks to isolate electrophysiological changes that may indicate disorders within the central and/or peripheral nervous system. Methods: A total of forty-two consecutive patients with myasthenia gravis (24 women, 18 men) were included in the study. All of the patients underwent EP examination. MR images were also analyzed. Results: In the group of MG patients, the latency of P100 (113.9 +/- 13.9; p < 0.0001) VEP, wave III (3.92 +/- 0.29; p = 0.015), wave V (5.93 +/- 0.32; <0.0001), interlatency III-V (2.00 +/- 0.12; p < 0.0001), interlatency I-V (4.20 +/- 0.28; p < 0.001) BAEP, and all components of SEP (N9, P10, N13, P16, N20, P22) were significantly longer. Mean wave I and V amplitude BAEP were relatively lower. Conclusions: The results of the study suggest the presence of disturbances in the bioelectric activities of the central and peripheral nervous system in MG patients.

Automated summary

The study identified significant changes in multiple parameters of visually evoked potentials, brainstem auditory evoked potentials, and somatosensory evoked potentials in patients with myasthenia gravis, suggesting disturbances in the bioelectric activities of the central and peripheral nervous system.