期刊
BRAIN SCIENCES
卷 11, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/brainsci11081060
关键词
primary progressive aphasia; frontotemporal dementia; Alzheimer's disease; neuropsychology; span; sentence repetition; working memory; phonological; visuospatial
资金
- National Health and Medical Research Council (NHMRC) [GNT1037746]
- Australian Research Council (ARC) Centre of Excellence in Cognition and its Disorders Memory Program [CE11000102]
- Australian Research Council [FT160100096, DP180101548]
- NHMRC [GNT1072451, GNT1103258]
- Australian Research Council [FT160100096] Funding Source: Australian Research Council
Impaired verbal 'phonological' short-term memory is a key feature of logopenic variant of primary progressive aphasia. Distinguishing between different PPA variants can be challenging due to overlapping language profiles, and a combination of verbal short-term and working memory measures is crucial for understanding language disturbances in PPA. Additionally, visuospatial span tasks are essential for assessing PPA without language contamination.
Impaired verbal 'phonological' short-term memory is considered a cardinal feature of the logopenic variant of primary progressive aphasia (lv-PPA) and is assumed to underpin most of the language deficits in this syndrome. Clinically, examination of verbal short-term memory in individuals presenting with PPA is common practice and serves two objectives: (i) to help understand the possible mechanisms underlying the patient's language profile and (ii) to help differentiate lv-PPA from other PPA variants or from other dementia syndromes. Distinction between lv-PPA and the non-fluent variant of PPA (nfv-PPA), however, can be especially challenging due to overlapping language profiles and comparable psychometric performances on verbal short-term memory tests. Here, we present case vignettes of the three PPA variants (lv-PPA, nfv-PPA, and the semantic variant (sv-PPA)) and typical Alzheimer's disease (AD). These vignettes provide a detailed description of the short-term and working memory profiles typically found in these patients and highlight how speech output and language comprehension deficits across the PPA variants differentially interfere with verbal memory performance. We demonstrate that a combination of verbal short-term and working memory measures provides crucial information regarding the cognitive mechanisms underlying language disturbances in PPA. In addition, we propose that analogous visuospatial span tasks are essential for the assessment of PPA as they measure memory capacity without language contamination.
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