Suppressive Antibiotic Treatment in Prosthetic Joint Infections: A Perspective

The treatment of prosthetic joint infections (PJIs) is a complex matter in which surgical, microbiological and pharmacological aspects must be integrated and, above all, placed in the context of each patient to make the best decision. Sometimes it is not possible to offer curative treatment of the infection, and in other cases, the probability that the surgery performed will be successful is considered very low. Therefore, indefinite administration of antibiotics with the intention of suppressing the course of the infection becomes useful. For decades, we had little information about suppressive antibiotic treatment (SAT). However, due to the longer life expectancy and increase in orthopaedic surgeries, an increasing number of patients with infected joint prostheses experience complex situations in which SAT should be considered as an alternative. In the last 5 years, several studies attempting to answer the many questions that arise on this issue have been published. The aim of this publication is to review the latest published evidence on SAT.

Automated summary

The treatment of prosthetic joint infections (PJIs) is a complex matter that requires integration of surgical, microbiological, and pharmacological aspects, while also taking into consideration each patient's individual context. In some cases, curative treatment may not be possible, leading to the importance of long-term antibiotic administration to suppress the infection.