Antimicrobial Peptides: A Potent Alternative to Antibiotics

Antimicrobial peptides constitute one of the most promising alternatives to antibiotics since they could be used to treat bacterial infections, especially those caused by multidrug-resistant pathogens. Many antimicrobial peptides, with various activity spectra and mechanisms of actions, have been described. This review focuses on their use against ESKAPE bacteria, especially in biofilm treatments, their synergistic activity, and their application as prophylactic agents. Limitations and challenges restricting therapeutic applications are highlighted, and solutions for each challenge are evaluated to analyze whether antimicrobial peptides could replace antibiotics in the near future.

Automated summary

Antimicrobial peptides are a promising alternative to antibiotics for treating bacterial infections, especially those caused by multidrug-resistant pathogens. They show various activity spectra and mechanisms of actions, and can be used synergistically against ESKAPE bacteria, particularly in biofilm treatments. Challenges and limitations in their therapeutic applications are highlighted, with potential solutions being evaluated to determine if antimicrobial peptides could potentially replace antibiotics in the future.