期刊
ANTIBIOTICS-BASEL
卷 10, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics10080995
关键词
antibiotic resistance; beta-lactamase inhibitor; beta-lactams; carbapenem; penicillin; cephalosporin
Beta-lactams are important antibiotics, but increasing resistance, especially among Gram-negative bacteria, poses a major threat to public health. Combining beta-lactam antibiotics with beta-lactamase inhibitors can help overcome resistance, but some beta-lactamases are resistant to existing inhibitors, leading to a need for new and more efficient inhibitors.
The beta-lactams have a central place in the antibacterial armamentarium, but the increasing resistance to these drugs, especially among Gram-negative bacteria, is becoming one of the major threats to public health worldwide. Treatment options are limited, and only a small number of novel antibiotics are in development. However, one of the responses to this threat is the combination of beta-lactam antibiotics with beta-lactamase inhibitors, which are successfully used in the clinic for overcoming resistance by inhibiting beta-lactamases. The existing inhibitors inactivate most of class A and C serine beta-lactamases, but several of class D and B (metallo-beta-lactamase) are resistant. The present review provides the status and knowledge concerning current beta-lactamase inhibitors and an update on research efforts to identify and develop new and more efficient beta-lactamase inhibitors.
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