期刊
ANTIBIOTICS-BASEL
卷 10, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics10070863
关键词
RND efflux pumps; drug resistance; cystic fibrosis
资金
- Italian Ministry of Education, University and Research (MIUR) (Dipartimenti di Eccellenza, Program 2018-2022)
This review summarizes the principal RND efflux pump families described in CF pathogens, with a focus on the main Gram-negative bacterial species, where RND pumps have been associated with MDR phenotypes.
Drug resistance represents a great concern among people with cystic fibrosis (CF), due to the recurrent and prolonged antibiotic therapy they should often undergo. Among Multi Drug Resistance (MDR) determinants, Resistance-Nodulation-cell Division (RND) efflux pumps have been reported as the main contributors, due to their ability to extrude a wide variety of molecules out of the bacterial cell. In this review, we summarize the principal RND efflux pump families described in CF pathogens, focusing on the main Gram-negative bacterial species (Pseudomonas aeruginosa, Burkholderia cenocepacia, Achromobacter xylosoxidans, Stenotrophomonas maltophilia) for which a predominant role of RND pumps has been associated to MDR phenotypes.
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