Natural Food Polysaccharides Ameliorate Inflammatory Bowel Disease and Its Mechanisms

Natural polysaccharides and their metabolites' short chain fatty acids (SCFAs) have attracted much attention. Recently, they have shown great potential in attenuating systemic inflammation activities, especially in inflammatory bowel disease (IBD). IBD is a complex pathological process and is related to epithelial damage and microbiota imbalance in the gut. Recent studies have indicated that natural polysaccharides could improve IBD recovery by different mechanisms. They could not only influence the ratio of intestine microbiota, but also regulate the secretion levels of immunity cytokines through multiple pathways, the latter including modulation of the TLR/MAPK/NF-kappa B signaling pathways and stimulation of G-protein-coupled receptors. Moreover, they could increase intestinal integrity and modulate oxidative stress. In this review, recent research about how natural polysaccharides impact the pathogenesis of IBD are summarized to prove the association between polysaccharides and disease recovery, which might contribute to the secretion of inflammatory cytokines, improve intestine epithelial damage, reduce oxidative stress, sustain the balanced microenvironment of the intestines, and finally lower the risk of IBD.

Automated summary

Natural polysaccharides and their metabolites, particularly short chain fatty acids (SCFAs), have shown promising potential in attenuating systemic inflammation, especially in the context of inflammatory bowel disease (IBD). Recent studies have highlighted the various mechanisms through which natural polysaccharides can impact IBD, including regulating intestinal microbiota ratios, modulating immune cytokines levels, and enhancing intestinal integrity. These effects contribute to reducing inflammation, improving intestinal health, and reducing the risk of IBD.