期刊
FOODS
卷 10, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/foods10061349
关键词
Lactobacillus ruminis; DSS-induced colitis; inflammatory cytokines; SCFAs; gut microbiota
资金
- National Natural Science Foundation of China [32021005]
- National First-Class Discipline Program of Food Science and Technology [JUFSTR20180102]
- Fundamental Research Funds for the Central Universities [JUSRP52003B]
- 111 Project [BP0719028]
- Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province
Lactobacillus ruminis showed immune regulatory effects in DSS-induced colitis mice by reducing pro-inflammatory cytokines and increasing short chain fatty acids, ultimately improving the imbalance of gut microbiota composition.
Lactobacillus ruminis can stimulate the immune response in vitro, but previous studies were only carried out in vitro and the anti-inflammatory effects of L. ruminis needs more in vivo evidences. In this study, the immune regulation and potential mechanisms of L. ruminis was investigated in DSS-induced colitis mice. L. ruminis FXJWS27L3 and L. ruminis FXJSW17L1 relieved the symptoms of colitis, including inhibition of colon shortening and colon tissue damage. L. ruminis FXJWS27L3 significantly reduced the pro-inflammatory cytokines IL-1 beta, TNF-alpha, and IL-17, while L. ruminis FXJSW17L1 significantly increased short chain fatty acids in mice feces. Moreover, L. ruminis FXJWS27L3 and L. ruminis FXJSW17L1 treatments significantly increased the gut microbiota diversity and balance the intestine microbiota profiles, which improved the imbalance of intestine microbiota composition to a certain extent. The results showed that L. ruminis can alleviate DSS-induced colitis, which possibly was related to promoting the expression of pro-inflammatory cytokines, up-regulating SCFAs and restoring the imbalance of gut microbiota.
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