期刊
FOODS
卷 10, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/foods10092036
关键词
Angelica keiskei; chalcone; anti-tumor; mechanism; apoptosis; cell cycle
资金
- Shandong Provincial Natural Science Foundation [ZR2019PH020]
The natural flavonoid compound 4-hydroxyderricin (4-HD) derived from Angelica keiskei shows significant inhibitory effects on hepatocellular carcinoma (HCC) cells, by promoting apoptosis and cell cycle arrest through the PI3K/AKT/mTOR signaling pathway.
4-hydroxyderricin (4-HD), as a natural flavonoid compound derived from Angelica keiskei, has largely unknown inhibition and mechanisms on liver cancer. Herein, we investigated the inhibitory effects of 4-HD on hepatocellular carcinoma (HCC) cells and clarified the potential mechanisms by exploring apoptosis and cell cycle arrest mediated via the PI3K/AKT/mTOR signaling pathway. Our results show that 4-HD treatment dramatically decreased the survival rate and activities of HepG2 and Huh7 cells. The protein expressions of apoptosis-related genes significantly increased, while those related to the cell cycle were decreased by 4-HD. 4-HD also down-regulated PI3K, p-PI3K, p-AKT, and p-mTOR protein expression. Moreover, PI3K inhibitor (LY294002) enhanced the promoting effect of 4-HD on apoptosis and cell cycle arrest in HCC cells. Consequently, we demonstrate that 4-HD can suppress the proliferation of HCC cells by promoting the PI3K/AKT/mTOR signaling pathway mediated apoptosis and cell cycle arrest.
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