期刊
FRONTIERS IN MARINE SCIENCE
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmars.2021.746811
关键词
Lateolabrax maculatus; fatty liver; mitochondrial biogenesis; mitophagy; endoplasmic reticulum stress
资金
- National Natural Science Foundation of China [32072984]
- Natural Science Foundation of Fujian Province [2020J01664]
- China Agriculture Research System [CARS-47]
This study found that quercetin can significantly inhibit fat deposition induced by a high-fat diet, possibly by activating mitochondrial biogenesis and autophagy while suppressing endoplasmic reticulum stress.
This study aimed to investigate the effects of quercetin (QUE) on fat deposition and the underlying mechanism. Fish were fed four test diets: normal fat diet (NFD), high-fat diet (HFD), and HFD supplemented with 0.5 or 1.0 g/kg quercetin (QUE0.5 or QUE1.0). The results showed that HFD feeding resulted in poor growth and feed utilization while QUE treatment reversed this. The fat contents of serum and liver were increased by HFD and QUE supplementation significantly decreased fat content. Furthermore, gene expressions and ultrastructure observation showed that mitochondrial biogenesis and mitophagy were inhibited and endoplasmic reticulum stress (ERS) in the HFD group. QUE can activate the biogenesis and autophagy of mitochondria and suppress ERS, which is related to its fat-lowering effect.
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