期刊
FRONTIERS IN MEDICINE
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmed.2021.737256
关键词
psoriatic arthritis; uveitis; inflammatory bowel disease; co-morbidity; biologic therapy
资金
- National Medical Research Council, Singapore [NMRC/CSA-Inv/0022/2017]
Psoriatic arthritis is a chronic inflammatory disease often associated with psoriasis and joint manifestations. While advancements have been made in understanding the disease and developing new treatments, the diverse comorbidities of PsA continue to present a clinical challenge in patient management.
Psoriatic arthritis (PsA) is a chronic inflammatory disease that presents with psoriasis (PsO), peripheral and axial arthropathy. The heterogeneity of disease presentation leads to the term psoriatic disease (PsD) which is thought to better encompass the range of clinical manifestations. PsA is associated with several comorbidities such as cardiovascular diseases, metabolic syndrome and other extra-articular manifestations including uveitis, and inflammatory bowel disease (IBD). While novel therapeutics are being developed following advances in our understanding of the pathogenesis of the disease, the diverse combinations of PsA with its various comorbidities still pose a clinical challenge in managing patients with PsA. This article reviews our current understanding of the pathogenesis of PsA and how various pathways in the pathogenesis lead to the two comorbid extra-articular manifestations - uveitis and IBD. We also review current evidence of treatment strategies in managing patients with PsA with comorbidities of uveitis and/or IBD.
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