期刊
PATHOGENS
卷 10, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/pathogens10070812
关键词
Strongyloides stercoralis; immunosuppression; ivermectin; PCR; population pharmacokinetics
类别
资金
- Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC)
The ImmunoStrong study aims to evaluate the effectiveness and safety of a single-dose ivermectin for treatment of uncomplicated strongyloidiasis in immunosuppressed patients, as well as to assess the accuracy of molecular techniques for patient follow-up. Additionally, the study seeks to determine the population pharmacokinetics of ivermectin.
Strongyloidiasis affects an estimated 600 million people worldwide, especially in tropical and subtropical areas. Single-dose ivermectin treatment has shown to be effective among immunocompetent patients with uncomplicated strongyloidiasis. Here, we present the protocol of the ImmunoStrong study, a prospective observational study aiming to evaluate the effectiveness and safety of a single-dose ivermectin for treatment of uncomplicated strongyloidiasis in immunosuppressed patients. The secondary objectives are to assess accuracy of molecular techniques for the follow-up of these patients and to determine the population pharmacokinetics of ivermectin. The information retrieved by this study will cover relevant information gaps in the strongyloidiasis management among immunosuppressed patients.
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