4.5 Article

IL-16 and BCA-1 Serum Levels Are Associated with Disease Severity of C. difficile Infection

期刊

PATHOGENS
卷 10, 期 5, 页码 -

出版社

MDPI
DOI: 10.3390/pathogens10050631

关键词

Clostridioides difficile; nosocomial infection; cytokines; chemokines; disease severity

资金

  1. Chief Scientist's Office of the Ministry of Health, Israel [3-000-14515]

向作者/读者索取更多资源

This study investigated the serum levels of six cytokines and chemokines in CDI patients and found an association between IL-16 and BCA-1 with disease severity. These cytokines and chemokines may serve as biomarkers for predicting CDI severity in the future, contributing to better patient outcomes.
Clostridioides difficile infection (CDI) is associated with a high risk for complications and death, which requires identifying severe patients and treating them accordingly. We examined the serum level of six cytokines and chemokines (IL-16, IL-21, IL-23, IL-33, BCA-1, TRAIL) and investigated the association between them and patients' disease severity. Concentrations of six cytokines and chemokines were measured using the MILLIPLEX(R)MAP kit (Billerica, MA, USA) in serum samples attained from CDI patients within 24-48 h after laboratory confirmation of C. difficile presence. Demographic and clinical data were collected from medical records. The disease severity score was determined according to guidelines of the Society for Healthcare Epidemiology of America and the Infectious Diseases Society of America (SHEA-IDSA). Out of 54 patients, 20 (37%) had mild to moderate disease and 34 (63%) had severe disease. IL-16 (p = 0.005) and BCA-1 (p = 0.012) were associated with a more severe disease. In conclusion, IL-16 and BCA-1, along with other cytokines and chemokines, may serve as biomarkers for the early prediction of CDI severity in the future. An improved and more accessible assessment of CDI severity will contribute to the adjustment of the medical treatment, which will lead to a better patient outcome.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据