期刊
FRONTIERS IN SYSTEMS NEUROSCIENCE
卷 15, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnsys.2021.711350
关键词
thalamus; nucleus accumbens; goal-directed; reward; addiction
资金
- F.R.S.-FNRS (Belgium)
- F.R.S.-FNRS
- Fondation Simone et Pierre Clerdent, ULB
- Fondation ULB
This review summarizes studies on the functional connectivity of thalamo-NAc afferents using techniques such as chemo- and optogenetics, electrophysiology, and in vivo calcium imaging, with a particular focus on projections from the Paraventricular Thalamus (PVT) to the NAc. Recent research has highlighted the importance and roles of these neuronal connections in motivated behaviors and addiction.
The ventral striatum, also called nucleus accumbens (NAc), has long been known to integrate information from cortical, thalamic, midbrain and limbic nuclei to mediate goal-directed behaviors. Until recently thalamic afferents have been overlooked when studying the functions and connectivity of the NAc. However, findings from recent studies have shed light on the importance and roles of precise Thalamus to NAc connections in motivated behaviors and in addiction. In this review, we summarize studies using techniques such as chemo- and optogenetics, electrophysiology and in vivo calcium imaging to elucidate the complex functioning of the thalamo-NAc afferents, with a particular highlight on the projections from the Paraventricular Thalamus (PVT) to the NAc. We will focus on the recent advances in the understanding of the roles of these neuronal connections in motivated behaviors, with a special emphasis on their implications in addiction, from cue-reward association to the mechanisms driving relapse.
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