期刊
FRONTIERS IN SYSTEMS NEUROSCIENCE
卷 15, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnsys.2021.655172
关键词
conductive hearing loss; resting state functional connectivity; structural MRI; diffusion tensor imaging; rat - brain
资金
- Research Grants Council of Hong Kong SAR, China HKPFS [PF16-07754]
- Medical Scientist Training Program NIH grant [T32 GM07170]
- General Program of National Natural Science Foundation of China [61671228, 61728107, 81871349]
- Technology R&D Program of Guangdong [2017B090912006, 2018B030333001]
- Early Career Scheme, Research Grants Council of Hong Kong [21201217]
This study assessed the effects of short-term conductive hearing loss on the auditory system using adult rat models, revealing structural and functional connectivity changes in the auditory cortex and inferior colliculus. The results suggest alterations in brain structure and function following short-term hearing loss in adults.
Conductive hearing loss (CHL) results in attenuation of air conducted sound reaching the inner ear. How a change in air conducted sound alters the auditory system resulting in cortical alterations is not well understood. Here, we have assessed structural and functional magnetic resonance imaging (MRI) in an adult (P60) rat model of short-term conductive hearing loss (1 week). Diffusion tensor imaging (DTI) revealed fractional anisotropy (FA) and axial diffusivity alterations after hearing loss that circumscribed the auditory cortex (AC). Tractography found the lateral lemniscus tract leading to the bilateral inferior colliculus (IC) was reduced. For baseline comparison, DTI and tractography alterations were not found for the somatosensory cortex. To determine functional connectivity changes due to hearing loss, seed-based analysis (SBA) and independent component analysis (ICA) were performed. Short term conductive hearing loss altered functional connectivity in the AC and IC, but not the somatosensory cortex. The results present an exploratory neuroimaging assessment of structural alterations coupled to a change in functional connectivity after conductive hearing loss. The results and implications for humans consist of structural-functional brain alterations following short term hearing loss in adults.
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