4.6 Article

Antimicrobial and Antibiofilm Activities of Weissella cibaria against Pathogens of Upper Respiratory Tract Infections

期刊

MICROORGANISMS
卷 9, 期 6, 页码 -

出版社

MDPI
DOI: 10.3390/microorganisms9061181

关键词

probiotic; antimicrobial; antibiofilm; upper respiratory tract; Weissella cibaria

资金

  1. Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through the Useful Agricultural Life Resources Industry Technology Development Program - Ministry of Agriculture, Food and Rural Affairs (MAFRA) [120050-2]
  2. Basic Science Research Program of the National Research Foundation of Korea - Ministry of Science and ICT (MSIT) of Korea [2020R1F1A1069551]
  3. National Research Foundation of Korea [2020R1F1A1069551] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

The study found that Weissella cibaria probiotics have excellent antimicrobial and antibiofilm properties, effectively killing various upper respiratory tract infection pathogens and inhibiting biofilm formation. This offers new possibilities for the prevention and treatment of bacterial upper respiratory tract infections.
Recently discovered preventive effects of probiotics on oral health have attracted interest to their use for the prevention and treatment of various diseases. This study aimed to evaluate the antimicrobial and antibiofilm properties of Weissella cibaria against Streptococcus pyogenes, Staphylococcus aureus, S. pneumoniae, and Moraxella catarrhalis, the major pathogens of upper respiratory tract infections (URTIs). The antimicrobial activities of W. cibaria were compared with those of other oral probiotics using a competitive inhibition assay and the determination of the minimum inhibitory concentrations (MICs). In addition, a time-kill assay, spectrophotometry, and confocal laser scanning microscopy were used to confirm the antimicrobial and antibiofilm abilities of W. cibaria CMU (oraCMU) and CMS1 (oraCMS1). Both live cells and cell-free supernatants of all tested probiotics, except Streptococcus salivarius, showed excellent antimicrobial activities. All target pathogens were killed within 4 to 24 h at twice the MIC of oraCMU and oraCMS1, which showed the highest antimicrobial activities against M. catarrhalis. The antimicrobial substances that affected different target pathogens were different. Both oraCMU and oraCMS1 showed excellent abilities to inhibit biofilm formation and remove preformed biofilms. Our results suggest that the W. cibaria probiotics offer new possibilities for the prevention and treatment of bacterial URTIs.

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