4.6 Review

Recent Advances in the Physicochemical Properties and Biotechnological Application of Vitreoscilla Hemoglobin

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Article Energy & Fuels

Bioethanol production from whey powder by immobilized E. coli expressing Vitreoscilla hemoglobin: optimization of sugar concentration and inoculum size

Taner Sar et al.

Summary: The study shows that the Vitreoscilla hemoglobin/immobilization system can enhance ethanol production, with strain TS3 producing higher yields compared to strain FBR5, and ethanol production increasing with lactose concentration.

BIOFUELS-UK (2021)

Article Biotechnology & Applied Microbiology

Improvement of pyrroloquinoline quinone-dependent D-sorbitol dehydrogenase activity from Gluconobacter oxydans via expression of Vitreoscilla hemoglobin and regulation of dissolved oxygen tension for the biosynthesis of 6-(N-hydroxyethyl)-amino-6-deoxy-α-L-sorbofuranose

Dong Liu et al.

Summary: In this study, the heterologous expression of Vitreoscilla hemoglobin (VHb) in Gluconobacter oxydans enhanced oxygen transfer efficiency and promoted respiration, resulting in increased biomass and improved production of the miglitol intermediate 6-(N-hydroxyethyl)-amino-6-deoxy-alpha-L-sorbofuranose (6NSL). Optimizing the dissolved oxygen concentration in a stirred bioreactor further increased the maximum volumetric oxidation activity of NHEG. The biotransformation of NHEG to 6NSL under controlled oxygen tension led to the accumulation of up to 87.5 +/- 5.9 g/L 6NSL within 16 hours.

JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2021)

Article Biotechnology & Applied Microbiology

Combining co-culturing of Paenibacillus strains and Vitreoscilla hemoglobin expression as a strategy to improve biodesulfurization

T. Sar et al.

Summary: The enhancement of desulfurization activities of Paenibacillus strains 32O-W and 32O-Y was investigated using different sulfur sources, with the co-culture of strains showing the best growth under specific conditions.

LETTERS IN APPLIED MICROBIOLOGY (2021)

Article Biotechnology & Applied Microbiology

Metabolic engineering of E. coli for pyocyanin production

Adilson Jose da Silva et al.

Summary: This study engineered the pyocyanin biosynthetic pathway for high production in a heterologous host for the first time. Optimized culture and induction parameters led to a 3.5-fold increase in pyocyanin accumulation, while pathway balancing through testing plasmids with different copy numbers resulted in a fourfold difference in product titer among the engineered strains. Co-expression of Vitreoscilla hemoglobin Vhb further improved pyocyanin production to a final titer of 18.8 mg/L, demonstrating the potential of using Escherichia coli for phenazines production in electro-fermentation systems.

METABOLIC ENGINEERING (2021)

Article Biotechnology & Applied Microbiology

Identification of a novel promoter for driving antibiotic-resistant genes to reduce the metabolic burden during protein expression and effectively select multiple integrations in Pichia Pastoris

Qi Shen et al.

Summary: A novel glucose-regulated promoter, P-Dog2p300, was identified for driving the expression of antibiotic-resistant genes in Pichia pastoris, resulting in reduced metabolic burden during recombinant protein expression. The use of P-Dog2p300 effectively selected transformants harboring multiple integrations in a cost-effective manner.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2021)

Article Biochemistry & Molecular Biology

High-Level Production of a Thermostable Mutant of Yarrowia lipolytica Lipase 2 in Pichia pastoris

Qinghua Zhou et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biotechnology & Applied Microbiology

Enhancement of glucaric acid production in Saccharomyces cerevisiae by expressing Vitreoscilla hemoglobin

Xi Zhang et al.

BIOTECHNOLOGY LETTERS (2020)

Article Biotechnology & Applied Microbiology

Physiological Response of Escherichia coli W3110 and BL21 to the Aerobic Expression of Vitreoscilla Hemoglobin

Alvaro R. Lara et al.

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2020)

Article Biotechnology & Applied Microbiology

Design of a synthetic miniR1 plasmid and its production by engineered Escherichia coli

Alvaro R. Lara et al.

BIOPROCESS AND BIOSYSTEMS ENGINEERING (2019)

Article Biotechnology & Applied Microbiology

Engineering E. coli for improved microaerobic pDNA production

Karim E. Jaen et al.

BIOPROCESS AND BIOSYSTEMS ENGINEERING (2019)

Article Biochemistry & Molecular Biology

Over-expression of Vitreoscilla hemoglobin (VHb) and flavohemoglobin (FHb) genes greatly enhances pullulan production

Si-Jia Xue et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

Article Biotechnology & Applied Microbiology

Heterologous overexpression of bacterial hemoglobin VHb improves erythritol biosynthesis by yeast Yarrowia lipolytica

Aleksandra M. Mironczuk et al.

MICROBIAL CELL FACTORIES (2019)

Article Biotechnology & Applied Microbiology

Enhanced production of poly-gamma-glutamic acid by improving ATP supply in metabolically engineered Bacillus licheniformis

Dongbo Cai et al.

BIOTECHNOLOGY AND BIOENGINEERING (2018)

Article Agriculture, Multidisciplinary

Enhanced S-Adenosylmethionine Production by Increasing ATP Levels in Baker's Yeast (Saccharomyces cerevisiae)

Yawei Chen et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

Article Biotechnology & Applied Microbiology

Increasing oxygen availability for improving poly(3-hydroxybutyrate) production by Halomonas

Pengfei Ouyang et al.

METABOLIC ENGINEERING (2018)

Article Environmental Sciences

An engineered Pseudomonas putida can simultaneously degrade organophosphates, pyrethroids and carbamates

Ting Gong et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2018)

Article Biochemistry & Molecular Biology

Enhancement of l-phenylalanine production in Escherichia coli by heterologous expression of Vitreoscilla hemoglobin

Wei-Bin Wu et al.

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2018)

Article Biotechnology & Applied Microbiology

Enhanced bacterial cellulose production by Gluconacetobacter xylinus via expression of Vitreoscilla hemoglobin and oxygen tension regulation

Miao Liu et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2018)

Article Biochemical Research Methods

Aerobic expression of Vitreoscilla hemoglobin improves the growth performance of CHO-K1 cells

Mariana Juarez et al.

BIOTECHNOLOGY JOURNAL (2017)

Article Biochemical Research Methods

Aerobic expression of Vitreoscilla hemoglobin improves the growth performance of CHO-K1 cells

Mariana Juarez et al.

BIOTECHNOLOGY JOURNAL (2017)

Article Biotechnology & Applied Microbiology

Synergic regulation of redox potential and oxygen uptake to enhance production of coenzyme Q10 in Rhodobacter sphaeroides

Yongqiang Zhu et al.

ENZYME AND MICROBIAL TECHNOLOGY (2017)

Article Biotechnology & Applied Microbiology

Expression of Vitreoscilla hemoglobin enhances production of arachidonic acid and lipids in Mortierella alpina

Huidan Zhang et al.

BMC BIOTECHNOLOGY (2017)

Article Biotechnology & Applied Microbiology

Enhancement of ganoderic acid production by constitutively expressing Vitreoscilla hemoglobin gene in Ganoderma lucidum

Huan-Jun Li et al.

JOURNAL OF BIOTECHNOLOGY (2016)

Review Biotechnology & Applied Microbiology

Recent trends in bioethanol production from food processing byproducts

Meltem Yesilcimen Akbas et al.

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2016)

Article Biotechnology & Applied Microbiology

Engineering synthetic bacterial consortia for enhanced desulfurization and revalorization of oil sulfur compounds

Igor Martinez et al.

METABOLIC ENGINEERING (2016)

Article Biotechnology & Applied Microbiology

Directed evolution to produce sludge communities with improved oxygen uptake abilities

Stephanie A. Kunkel et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2015)

Review Biotechnology & Applied Microbiology

Recent applications of Vitreoscilla hemoglobin technology in bioproduct synthesis and bioremediation

Benjamin C. Stark et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2015)

Article Biotechnology & Applied Microbiology

Construction and Characterization of Vitreoscilla Hemoglobin (VHb) with Enhanced Peroxidase Activity for Efficient Degradation of Textile Dye

Zidong Zhang et al.

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2015)

Article Biotechnology & Applied Microbiology

Effects of cascaded vgb promoters on poly(hydroxybutyrate) (PHB) synthesis by recombinant Escherichia coli grown micro-aerobically

Hong Wu et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2014)

Article Biochemistry & Molecular Biology

Improved ethanol production from cheese whey, whey powder, and sugar beet molasses by Vitreoscilla hemoglobin expressing Escherichia coli

Meltem Yesilcimen Akbas et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2014)

Article Agriculture, Multidisciplinary

Enhanced Production of Fatty Acids and Astaxanthin in Aurantiochytrium sp by the Expression of Vitreoscilla Hemoglobin

Yung Lee Suen et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2014)

Article Biochemical Research Methods

Crystallographic structure determination of B10 mutants of Vitreoscilla hemoglobin: role of Tyr29 (B10) in the structure of the ligand-binding site

Sireesha Ratakonda et al.

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2013)

Article Biochemistry & Molecular Biology

Reactivity and Dynamics of H2S, NO, and O2 Interacting with Hemoglobins from Lucina pectinata

Cacimar Ramos-Alvarez et al.

BIOCHEMISTRY (2013)

Article Biochemistry & Molecular Biology

pH-induced quaternary assembly of Vitreoscilla hemoglobin: The monomer exhibits better peroxidase activity

Wei Li et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2013)

Article Biotechnology & Applied Microbiology

Effect of substrate and IPTG concentrations on the burden to growth of Escherichia coli on glycerol due to the expression of Lac proteins

Pushkar Malakar et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2012)

Article Agricultural Engineering

Vitreoscilla hemoglobin enhances ethanol production by Escherichia coli in a variety of growth media

Marina Arnaldos et al.

BIOMASS & BIOENERGY (2012)

Article Biotechnology & Applied Microbiology

Enhancing macrolide production in Streptomyces by coexpressing three heterologous genes

Tao Wang et al.

ENZYME AND MICROBIAL TECHNOLOGY (2012)

Article Biotechnology & Applied Microbiology

Vitreoscilla Hemoglobin (VHb) Overexpression Increases Hypoxia Tolerance in Zebrafish (Danio rerio)

Bo Guan et al.

MARINE BIOTECHNOLOGY (2011)

Article Biotechnology & Applied Microbiology

Engineering of ethanolic E. coli with the Vitreoscilla hemoglobin gene enhances ethanol production from both glucose and xylose

Tony Sanny et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2010)

Article Biotechnology & Applied Microbiology

High-level Production of Recombinant Arenicola Marina Globin Chains in Escherichia Coli: A New Generation of Blood Substitute

Thomas Harnois et al.

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY (2009)

Article Hematology

Exogenous iron increases hemoglobin in β-thalassemic mice

Yelena Z. Ginzburg et al.

EXPERIMENTAL HEMATOLOGY (2009)

Article Plant Sciences

Heterologous expression of Vitreoscilla haemoglobin in barley (Hordeum vulgare)

Annika Wilhelmson et al.

PLANT CELL REPORTS (2007)

Article Biochemistry & Molecular Biology

An investigation of the peroxidase activity of Vitreoscilla hemoglobin

Malin Kvist et al.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2007)

Article Biotechnology & Applied Microbiology

Enhancement of biodesulfurization in two-liquid systems by heterogeneous expression of Vitreoscilla hemoglobin

Xiaochao Xiong et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2007)

Article Biochemistry & Molecular Biology

Interaction of Vitreoscilla hemoglobin with membrane lipids

AC Rinaldi et al.

BIOCHEMISTRY (2006)

Article Biotechnology & Applied Microbiology

Degradation of benzene, toluene and xylene by Pseudomonas aeruginosa engineered with the Vitreoscilla hemoglobin gene

H Kahraman et al.

ENGINEERING IN LIFE SCIENCES (2005)

Article Biotechnology & Applied Microbiology

Enhanced production of acetoin and butanediol in recombinant Enterobacter aerogenes carrying Vitreoscilla hemoglobin gene

H Geckil et al.

BIOPROCESS AND BIOSYSTEMS ENGINEERING (2004)

Article Biochemistry & Molecular Biology

The bacA gene of Escherichia coli encodes an undecaprenyl pyrophosphate phosphatase activity

M El Ghachi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biotechnology & Applied Microbiology

Gene expression profiling of Escherichia coli expressing double Vitreoscilla haemoglobin

V Roos et al.

JOURNAL OF BIOTECHNOLOGY (2004)

Article Biochemistry & Molecular Biology

Vitreoscilla hemoglobin binds to subunit I of cytochrome bo ubiquinol oxidases

KW Park et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Vitreoscilla hemoglobin -: Intracellular localization and binding to membranes

Ramandeep et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)