Coordinate Induction of Humoral and Spike Specific T-Cell Response in a Cohort of Italian Health Care Workers Receiving BNT162b2 mRNA Vaccine

Article Infectious Diseases

A whole blood test to measure SARS-CoV-2-specific response in COVID-19 patients

Linda Petrone et al.

Summary: The study showed that specific T cell responses to SARS CoV 2 peptides can be detected in COVID-19 patients and are significantly different from individuals without COVID-19. This immune response exhibits characteristics of both Th1 and Th2 profiles, potentially serving as a new T cell-based diagnostic tool.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Article Multidisciplinary Sciences

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Jennifer M. Dan et al.

Summary: Different components of immune memory to SARS-CoV-2 exhibit distinct kinetics, with antibodies and spike-specific memory B cells remaining relatively stable over 6 months, while CD4(+) T cells and CD8(+) T cells declining with a half-life of 3 to 5 months after infection.

SCIENCE (2021)

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Article Public, Environmental & Occupational Health

Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and Frontline Workers - Eight US Locations, December 2020-March 2021

Mark G. Thompson et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

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Article Immunology

Cellular Immunity in COVID-19 Convalescents with PCR-Confirmed Infection but with Undetectable SARS-CoV-2-Specific IgG

Sina Schwarzkopf et al.

Summary: The study found that in convalescent patients, immunity against SARS-CoV-2 may be mediated through T cells even in the absence of detectable IgG antibodies.

EMERGING INFECTIOUS DISEASES (2021)

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Review Immunology