期刊
MICROORGANISMS
卷 9, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/microorganisms9081575
关键词
human papillomavirus; multinucleated cell; koilocyte; Papanicolaou test; microdissection; cervical intraepithelial neoplasia
类别
资金
- JSPS KAKENHI [JP21K17274]
- Japan Agency for Medical Research and Development, AMED [JP21fk0108103]
This study found an association between HPV genotypes and MNCs, high-risk HPV genotypes may be related to atypical changes in MNC morphology, and MNCs may predict squamous intraepithelial lesions.
Many genotypes of human papillomaviruses (HPVs) may lead to morphological changes in cells, resulting in various atypical cells, such as multinucleated cells (MNCs) and koilocytes, in the cervix. However, the relationships between the profiles of HPV genotypes and MNCs are not exactly known. Thus, this study comprehensively profiles the HPV genotypes in MNCs using a microdissection method. HPV genotypes and MNCs were detected in 651 cases with an abnormal Pap smear by liquid-based cytology. Specific HPV genotypes were also detected, including HPV16, 34, and 56, which might be associated with MNCs. This result suggests that the high-risk HPV genotypes, such as HPV16 and 56, are associated with the atypical changes in MNC morphology from normal cervical cells. The results also show that MNCs may be a predictor of squamous intraepithelial lesion.
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