相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Central nervous system myeloid cells as drug targets: current status and translational challenges
Knut Biber et al.
NATURE REVIEWS DRUG DISCOVERY (2016)
Drug-repositioning opportunities for cancer therapy: novel molecular targets for known compounds
Roberto Wuerth et al.
DRUG DISCOVERY TODAY (2016)
The potassium channel KCa3.1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke
Yi-Je Chen et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2016)
Drug Repurposing for the Development of Novel Analgesics
Marco Sisignano et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2016)
Ion Channels in Innate and Adaptive Immunity
Stefan Feske et al.
ANNUAL REVIEW OF IMMUNOLOGY VOL 33 (2015)
Metabotropic glutamate receptors as drug targets: what's new?
Ferdinando Nicoletti et al.
CURRENT OPINION IN PHARMACOLOGY (2015)
Drug repositioning and repurposing: terminology and definitions in literature
Joris Langedijk et al.
DRUG DISCOVERY TODAY (2015)
IKCa Channels Are a Critical Determinant of the Slow AHP in CA1 Pyramidal Neurons
Brian King et al.
CELL REPORTS (2015)
KCa3:1/IK1 channel regulation by cGMP-dependent protein kinase (PKG) via reactive oxygen species and CaMKII in microglia: an immune modulating feedback system?
Roger Ferreira et al.
FRONTIERS IN IMMUNOLOGY (2015)
Microglial K+ Channel Expression in Young Adult and Aged Mice
Tom Schilling et al.
GLIA (2015)
Neuronal expression of the intermediate conductance calcium-activated potassium channel KCa3.1 in the mammalian central nervous system
Ray W. Turner et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2015)
Blood-Brain Barrier KCa3.1 Channels Evidence for a Role in Brain Na Uptake and Edema in Ischemic Stroke
Yi-Je Chen et al.
STROKE (2015)
KCa3.1 Modulates Neuroblast Migration Along the Rostral Migratory Stream (RMS) In Vivo
Kathryn L. Turner et al.
CEREBRAL CORTEX (2014)
Targeting of microglial Kca3.1 channels by TRAM-34 exacerbates hippocampal neurodegeneration and does not affect ictogenesis and epileptogenesis in chronic temporal lobe epilepsy models
Tanja Ongerth et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2014)
IL-4 type 1 receptor signaling up-regulates KCNN4 expression, and increases the KCa3.1 current and its contribution to migration of alternative-activated microglia
Roger Ferreira et al.
Frontiers in Cellular Neuroscience (2014)
Target validation using chemical probes
Mark E. Bunnage et al.
NATURE CHEMICAL BIOLOGY (2013)
Glial cell changes in epilepsy: Overview of the clinical problem and therapeutic opportunities
Jacqueline A. Hubbard et al.
NEUROCHEMISTRY INTERNATIONAL (2013)
TRAM-34, a Putatively Selective Blocker of Intermediate-Conductance, Calcium-Activated Potassium Channels, Inhibits Cytochrome P450 Activity
Jay J. Agarwal et al.
PLOS ONE (2013)
Selective Activation of KCa3.1 and CRAC Channels by P2Y2 Receptors Promotes Ca2+ Signaling, Store Refilling and Migration of Rat Microglial Cells
Roger Ferreira et al.
PLOS ONE (2013)
Cancer drug discovery by repurposing: teaching new tricks to old dogs
Subash C. Gupta et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2013)
KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo
G. D'Alessandro et al.
CELL DEATH & DISEASE (2013)
Drug repositioning for Alzheimer's disease
Anne Corbett et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Genetic KCa3.1-Deficiency Produces Locomotor Hyperactivity and Alterations in Cerebral Monoamine Levels
Kate Lykke Lambertsen et al.
PLOS ONE (2012)
Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells
Jordan D. T. Engbers et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
What Happened to Anti-CD33 Therapy for Acute Myeloid Leukemia?
Joseph G. Jurcic
CURRENT HEMATOLOGIC MALIGNANCY REPORTS (2012)
Ion channels and transporters in lymphocyte function and immunity
Stefan Feske et al.
NATURE REVIEWS IMMUNOLOGY (2012)
Drug repositioning for orphan diseases
Divya Sardana et al.
BRIEFINGS IN BIOINFORMATICS (2011)
Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: a phase III randomized, placebo-controlled, double-blind study of the gardos channel blocker senicapoc (ICA-17043)
Kenneth I. Ataga et al.
BRITISH JOURNAL OF HAEMATOLOGY (2011)
Ion Channels on Microglia: Therapeutic Targets for Neuroprotection
Stephen D. Skaper
CNS & Neurological Disorders-Drug Targets (2011)
The lymphocyte potassium channels Kv1.3 and KCa3.1 as targets for immunosuppression
Jenny Lam et al.
DRUG DEVELOPMENT RESEARCH (2011)
Amyloid-β Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity
Izumi Maezawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke
Yi-Je Chen et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2011)
Inhibition of the Ca2+-Dependent K+ Channel, KCNN4/KCa3.1, Improves Tissue Protection and Locomotor Recovery after Spinal Cord Injury
Delphine Bouhy et al.
JOURNAL OF NEUROSCIENCE (2011)
Control of hypothalamic-pituitary-adrenal stress axis activity by the intermediate conductance calcium-activated potassium channel, SK4
Zhi Liang et al.
JOURNAL OF PHYSIOLOGY-LONDON (2011)
Ion channels in monocytes and microglia brain macrophages: Promising therapeutic targets for neurological diseases
Claudia Eder
JOURNAL OF NEUROIMMUNOLOGY (2010)
The art of the chemical probe
Stephen V. Frye
NATURE CHEMICAL BIOLOGY (2010)
Inhibition of the K+ channel KCa3.1 ameliorates T cell-mediated colitis
Lie Di et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Therapeutic potential of KCa3.1 blockers: recent advances and promising trends
Heike Wulff et al.
Expert Review of Clinical Pharmacology (2010)
Senicapoc (ICA-17043): a potential therapy for the prevention and treatment of hemolysis-associated complications in sickle cell anemia
Kenneth I. Ataga et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2009)
Non-Selective Cation Channel Activity Is Required for Lysophosphatidylcholine-Induced Monocyte Migration
Tom Schilling et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Expansion of the Time Window for Treatment of Acute Ischemic Stroke With Intravenous Tissue Plasminogen Activator A Science Advisory From the American Heart Association/American Stroke Association
Gregory J. del Zoppo et al.
STROKE (2009)
Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia
Kenneth I. Ataga et al.
BLOOD (2008)
Blunted IgE-mediated activation of mast cells in mice lacking the Ca2+-activated K+ channel KCa3.1
Ekaterina Shumilina et al.
JOURNAL OF IMMUNOLOGY (2008)
Novel inhibitors of the Gardos channel for the treatment of sickle cell disease
Grant A. McNaughton-Smith et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Ion channel expression in resting and activated microglia of hippocampal slices from juvenile mice
Tom Schilling et al.
BRAIN RESEARCH (2007)
Microglia: active sensor and versatile effector cells in the normal and pathologic brain
Uwe-Karsten Hanisch et al.
NATURE NEUROSCIENCE (2007)
TRAM-34 inhibits nonselective cation channels
Tom Schilling et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)
The Ca2+-activated K+ channel KCNN4/KCa3.1 contributes to microglia activation and nitric oxide-dependent neurodegeneration
Vikas Kaushal et al.
JOURNAL OF NEUROSCIENCE (2007)
Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications
Heike Wulff et al.
CURRENT MEDICINAL CHEMISTRY (2007)
Pain signalling pathways: From cytokines to ion channels
Kenji Okuse
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)
Dose-escalation study of ICA-17043 in patients with sickle cell disease
Kenneth I. Ataga et al.
PHARMACOTHERAPY (2006)
Expression and function of calcium-activated potassium channels in human glioma cells
Amy K. Weaver et al.
GLIA (2006)
Microglia Biology in Health and Disease
Gwenn A. Garden et al.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2006)
International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels
AD Wei et al.
PHARMACOLOGICAL REVIEWS (2005)
Blocking ion channel KCNN4 alleviates the symptoms of experimental autoimmune encephalomyelitis in mice
EP Reich et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2005)
IKCa-channel blockers.: Part 2:: Discovery of cyclohexadienes
K Urbahns et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
The distribution of small and intermediate conductance calcium-activated potassium channels in the rat sensory nervous system
LC Mongan et al.
NEUROSCIENCE (2005)
Functional importance of Ca2+-activated K+ channels for lysophosphatidic acid-induced microglial migration
T Schilling et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2004)
Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole
K Hill et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2004)
Selective intermediate-/small-conductance calcium-activated potassium channel (KCNN4) blockers are potent and effective therapeutics in experimental brain oedema and traumatic brain injury caused by acute subdural haematoma
F Mauler et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2004)
4-phenyl-4H-pyrans as IKCa channel blockers
K Urbahns et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Calcium-activated potassium channel SK1- and IK1-like immunoreactivity in injured human sensory neurones and its regulation by neurotrophic factors
MK Boettger et al.
BRAIN (2002)
Inhibition of cytochromes P450 by antifungal imidazole derivatives
WJ Zhang et al.
DRUG METABOLISM AND DISPOSITION (2002)
Lysophospholipids induce membrane hyperpolarization in microglia by activation of IKCa1Ca(2+)-dependent K+ channels
T Schilling et al.
NEUROSCIENCE (2002)
Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1
H Wulff et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1:: A potential immunosuppressant
H Wulff et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Effects of imidazole antimycotics on the liver microsomal cytochrome P450 isoforms in rats:: comparison of in vitro and ex vivo studies
S Suzuki et al.
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS (2000)