期刊
ANTIOXIDANTS
卷 10, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/antiox10060960
关键词
Zizania latifolia; antioxidant; heme oxygenase-1; nuclear factor erythroid-2-related factor 2; hepatoprotective
资金
- Technology development Program - Ministry of SMEs and Startups (MSS, Korea) [S2777824]
- Korea Technology & Information Promotion Agency for SMEs (TIPA) [S2777824] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The study indicates that pre-treatment with ETZL can effectively reduce alcohol-induced liver injury, decrease oxidative stress, and enhance antioxidant defense mechanisms.
Binge drinking patterns easily produce a state of oxidative stress that disturbs liver function. Eventually, this leads to alcoholic liver disease. A safe and effective therapy for alcoholic liver disease remains elusive. Enzyme-treated Z. latifolia extract (ETZL) was studied as a potential agent for treating alcohol-induced liver disease. In addition, its underlying mechanisms were elucidated. In the binge model, ETZL was pretreated with alcohol (5 g/kg) three times at 12-h intervals. Our results showed that ETZL pretreatment decreased the serum levels of ALT, AST, ALP, and TG. ETZL treatment appeared to prevent an increase in hepatic TG and MDA levels, and there was a decrease in total GSH following alcohol treatment. Histopathological examination showed that lipid droplets were significantly reduced in the ETZL group compared to the control group. ETZL also exhibited radical scavenging activity. It significantly reduced t-BHP-induced cytotoxicity and the production of reactive oxygen species (ROS) in HepG2 cells. ETZL also enhanced NRF2 nuclear translocation and increased expression of the downstream target genes HO-1, NQO1, and GCLC as an antioxidant defense. Finally, ETZL treatment significantly reduced cell death. Our study suggests that ETZL ameliorates binge ethanol-induced liver injury by upregulating the antioxidant defense mechanism.
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