期刊
ANTIOXIDANTS
卷 10, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/antiox10071024
关键词
sterol; oxidation; antioxidant; lipids; yeast; plasma membrane
资金
- Regional Council of Bourgogne, Franche Comte
- Fonds Europeen de DEveloppement Regional [FEDER BG0013217]
- AgroSup Dijon
Although the functions and structural roles of sterols have been extensively studied, the reasons for the variety of sterols in different eukaryotic kingdoms remain unclear. This study demonstrates the antioxidant properties of ergosterol and suggests explanations for its specific accumulation in late branching fungi. Ergosterol, as a natural antioxidant, may also contribute to the health benefits associated with some mushrooms.
Although the functions and structural roles of sterols have been the subject of numerous studies, the reasons for the diversity of sterols in the different eukaryotic kingdoms remain unclear. It is thought that the specificity of sterols is linked to unidentified supplementary functions that could enable organisms to be better adapted to their environment. Ergosterol is accumulated by late branching fungi that encounter oxidative perturbations in their interfacial habitats. Here, we investigated the antioxidant properties of ergosterol using in vivo, in vitro, and in silico approaches. The results showed that ergosterol is involved in yeast resistance to tert-butyl hydroperoxide and protects lipids against oxidation in liposomes. A computational study based on quantum chemistry revealed that this protection could be related to its antioxidant properties operating through an electron transfer followed by a proton transfer mechanism. This study demonstrates the antioxidant role of ergosterol and proposes knowledge elements to explain the specific accumulation of this sterol in late branching fungi. Ergosterol, as a natural antioxidant molecule, could also play a role in the incompletely understood beneficial effects of some mushrooms on health.
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