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ROS Defense Systems and Terminal Oxidases in Bacteria

期刊

ANTIOXIDANTS
卷 10, 期 6, 页码 -

出版社

MDPI
DOI: 10.3390/antiox10060839

关键词

bacteria; redox enzymes; terminal oxidases; reactive oxygen species; oxidative stress

资金

  1. Russian Foundation for Basic Research [19-04-00094]
  2. Sapienza [RP120172B8B36A98]

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Reactive oxygen species (ROS) can damage various macromolecules and compromise cell viability, prompting bacteria to utilize different defense mechanisms, such as ROS scavenging enzymes. Additionally, some terminal oxidases in bacterial respiratory chains may also play a protective role against ROS, as suggested by recent findings.
Reactive oxygen species (ROS) comprise the superoxide anion (O-2(center dot-)), hydrogen peroxide (H2O2), hydroxyl radical ((OH)-O-center dot), and singlet oxygen (O-1(2)). ROS can damage a variety of macromolecules, including DNA, RNA, proteins, and lipids, and compromise cell viability. To prevent or reduce ROS-induced oxidative stress, bacteria utilize different ROS defense mechanisms, of which ROS scavenging enzymes, such as superoxide dismutases, catalases, and peroxidases, are the best characterized. Recently, evidence has been accumulating that some of the terminal oxidases in bacterial respiratory chains may also play a protective role against ROS. The present review covers this role of terminal oxidases in light of recent findings.

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