期刊
ANTIOXIDANTS
卷 10, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/antiox10081244
关键词
antioxidant enzymes; aneurysm; atherosclerosis; cardiovascular diseases; hydrogen peroxide; oxidative stress; peroxiredoxins; reactive oxygen species
资金
- Korea Research Institute of Bioscience and Biotechnology (KRIBB) Research Initiative Program [KGM5272151]
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2020R1A3B2079811]
- Basic Science Research Program of the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2021R1I1A2056805]
- National Research Council of Science & Technology (NST), Republic of Korea [KGM5272151] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Increased oxidative stress is considered a common factor in the pathogenesis of cardiovascular disease, with precise regulation of ROS in cardiovascular cells essential for normal physiological functions. Antioxidant enzymes such as Prdxs play a crucial role in maintaining the balance of ROS levels and act as regulatory sensors of intracellular signals.
Increased oxidative stress (OS) is considered a common etiology in the pathogenesis of cardiovascular disease (CVD). Therefore, the precise regulation of reactive oxygen species (ROS) in cardiovascular cells is essential to maintain normal physiological functions. Numerous regulators of cellular homeostasis are reportedly influenced by ROS. Hydrogen peroxide (H2O2), as an endogenous ROS in aerobic cells, is a toxic substance that can induce OS. However, many studies conducted over the past two decades have provided substantial evidence that H2O2 acts as a diffusible intracellular signaling messenger. Antioxidant enzymes, including superoxide dismutases, catalase, glutathione peroxidases, and peroxiredoxins (Prdxs), maintain the balance of ROS levels against augmentation of ROS production during the pathogenesis of CVD. Especially, Prdxs are regulatory sensors of transduced intracellular signals. The intracellular abundance of Prdxs that specifically react with H2O2 act as regulatory proteins. In this review, we focus on the role of Prdxs in the regulation of ROS-induced pathological changes in the development of CVD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据