期刊
ANTIOXIDANTS
卷 10, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/antiox10071138
关键词
flavonoids; autophagy; cancer prevention; cancer therapy; nanotechnology
资金
- National Natural Science Foundation of China [81821002, 81790251]
- National Key Research and Development Project [2020YFA0509400, 2020YFC2002705]
- Guangdong Basic and Applied Basic Research Foundation [2019B030302012]
Flavonoids are considered safe and readily obtainable molecules that have potential in cancer treatment by modulating autophagy. However, their anti-cancer activity may be weakened by the induction of protective autophagy. Research is focusing on exploring new applications and dosage forms to establish flavonoids as ideal candidates for cancer prevention and therapy in clinical settings.
Flavonoids are considered as pleiotropic, safe, and readily obtainable molecules. A large number of recent studies have proposed that flavonoids have potential in the treatment of tumors by the modulation of autophagy. In many cases, flavonoids suppress cancer by stimulating excessive autophagy or impairing autophagy flux especially in apoptosis-resistant cancer cells. However, the anti-cancer activity of flavonoids may be attenuated due to the simultaneous induction of protective autophagy. Notably, flavonoids-triggered protective autophagy is becoming a trend for preventing cancer in the clinical setting or for protecting patients from conventional therapeutic side effects in normal tissues. In this review, focusing on the underlying autophagic mechanisms of flavonoids, we hope to provide a new perspective for clinical application of flavonoids in cancer therapy. In addition, we highlight new research ideas for the development of new dosage forms of flavonoids to improve their various pharmacological effects, establishing flavonoids as ideal candidates for cancer prevention and therapy in the clinic.
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