期刊
ANTIOXIDANTS
卷 10, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/antiox10081206
关键词
skin health; aging; plant extracts; natural products; phytochemistry; Sideritis scardica; Rosa damascena; senescence; photoprotection; proteasome
资金
- European Union (European Regional Development Fund-ERDF)
- National Strategic Reference Framework (NSRF)-Research [ENGAGE-11S~N_1_420]
- European Union (ERDF)
- Operational Program Competitiveness, Entrepreneurship and Innovation [5002691, 5002803]
This study conducted an extensive screening among approximately 6000 plant species in Greece, identifying extracts with antioxidant, photoprotective, anti-melanogenic, and anti-aging properties that could be valuable for the cosmetic industry.
Skin health is heavily affected by ultraviolet irradiation from the sun. In addition, senile skin is characterized by major changes in the collagen, elastin and in the hyaluronan content. Natural products (NPs) have been shown to delay cellular senescence or in vivo aging by regulating age-related signaling pathways. Moreover, NPs are a preferable source of photoprotective agents and have been proven to be useful against the undesirable skin hyperpigmentation. Greek flora harvests great plant diversity with approximately 6000 plant species, as it has a wealth of NPs. Here, we report an extensive screening among hundreds of plant species. More than 440 plant species and subspecies were selected and evaluated. The extracts were screened for their antioxidant and anti-melanogenic properties, while the most promising were further subjected to various in vitro and cell-based assays related to skin aging. In parallel, their chemical profile was analyzed with High-Performance Thin-Layer Chromatography (HPTLC) and/or Ultra-Performance Liquid Chromatography High-Resolution Mass Spectrometry (UPLC-HRMS). A variety of extracts were identified that can be of great value for the cosmetic industry, since they combine antioxidant, photoprotective, anti-melanogenic and anti-aging properties. In particular, the methanolic extracts of Sideritis scardica and Rosa damascena could be worthy of further attention, since they showed interesting chemical profiles and promising properties against specific targets involved in skin aging.
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