期刊
BIOMOLECULES
卷 11, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/biom11081240
关键词
skin fibrosis; keloid; fibroblasts; TGF-beta 1 signaling; pinocembrin
资金
- National Natural Science Foundation of China [82070060, 82000073]
- Foundation of Tianjin Pharmaceutical Group Co., Ltd. [735-F1025301]
Pinocembrin has been shown to effectively suppress skin fibrosis by inhibiting the proliferation and migration of keloid fibroblasts and dermal fibroblasts. In vivo experiments have also confirmed the therapeutic potential of pinocembrin for skin fibrosis.
Skin fibrotic diseases, such as keloids, are mainly caused by pathologic scarring of wounds during healing and characterized by benign cutaneous overgrowths of dermal fibroblasts. Current surgical and therapeutic modalities of skin fibrosis are unsatisfactory. Pinocembrin, a natural flavonoid, has been shown to possess a vast range of pharmacological activities including antimicrobial, antioxidant, anti-inflammatory, and anti-tumor activities. In this study we explored the potential effect and mechanisms of pinocembrin on skin fibrosis in vitro and in vivo. In vitro studies indicated that pinocembrin dose-dependently suppressed proliferation, migration, and invasion of keloid fibroblasts and mouse primary dermal fibroblasts. The in vivo studies showed that pinocembrin could effectively alleviate bleomycin (BLM)-induced skin fibrosis and reduce the gross weight and fibrosis-related protein expression of keloid tissues in xenograft mice. Further mechanism studies indicated that pinocembrin could suppress TGF-beta 1/Smad signaling and attenuate TGF-beta 1-induced activation of skin fibroblasts. In conclusion, our results demonstrate the therapeutic potential of pinocembrin for skin fibrosis.
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