4.7 Review

The Bigger Picture: Why Oral Mucosa Heals Better Than Skin

期刊

BIOMOLECULES
卷 11, 期 8, 页码 -

出版社

MDPI
DOI: 10.3390/biom11081165

关键词

wound healing; skin; oral; saliva; microbiome; scar; cytokines; growth factors

资金

  1. Dutch Burns Foundation [WO/16.107]

向作者/读者索取更多资源

Oral mucosa heals faster, shows a more rapid immune response, and undergoes increased extracellular matrix remodeling compared to skin, leading to superior wound healing and reduced scar formation.
Wound healing is an essential process to restore tissue integrity after trauma. Large skin wounds such as burns often heal with hypertrophic scarring and contractures, resulting in disfigurements and reduced joint mobility. Such adverse healing outcomes are less common in the oral mucosa, which generally heals faster compared to skin. Several studies have identified differences between oral and skin wound healing. Most of these studies however focus only on a single stage of wound healing or a single cell type. The aim of this review is to provide an extensive overview of wound healing in skin versus oral mucosa during all stages of wound healing and including all cell types and molecules involved in the process and also taking into account environmental specific factors such as exposure to saliva and the microbiome. Next to intrinsic properties of resident cells and differential expression of cytokines and growth factors, multiple external factors have been identified that contribute to oral wound healing. It can be concluded that faster wound closure, the presence of saliva, a more rapid immune response, and increased extracellular matrix remodeling all contribute to the superior wound healing and reduced scar formation in oral mucosa, compared to skin.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据