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FRONTIERS IN NEUROANATOMY (2014)
Amyloid-β and Tau The Trigger and Bullet in Alzheimer Disease Pathogenesis
George S. Bloom
JAMA NEUROLOGY (2014)
Curcumin Modulates α-Synuclein Aggregation and Toxicity
Pradeep K. Singh et al.
ACS CHEMICAL NEUROSCIENCE (2013)
Biology and Genetics of Prions Causing Neurodegeneration
Stanley B. Prusiner
ANNUAL REVIEW OF GENETICS, VOL 47 (2013)
Green tea (-)epigallocatechin-3-gallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia
Regina Biasibetti et al.
BEHAVIOURAL BRAIN RESEARCH (2013)
Epigallocatechin-3-gallate prevents systemic inflammation-induced memory deficiency and amyloidogenesis via its anti-neuroinflammatory properties
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JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2013)
Biocompatible, Functional Spheres Based on Oxidative Coupling Assembly of Green Tea Polyphenols
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Toward the Molecular Mechanism(s) by Which EGCG Treatment Remodels Mature Amyloid Fibrils
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
The many faces of alpha-synuclein: from structure and toxicity to therapeutic target
Hilal A. Lashuel et al.
NATURE REVIEWS NEUROSCIENCE (2013)
Polyphenols: Multipotent Therapeutic Agents in Neurodegenerative Diseases
Khushwant S. Bhullar et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)
Alternative Pathways of Human Islet Amyloid Polypeptide Aggregation Distinguished by 19F Nuclear Magnetic Resonance-Detected Kinetics of Monomer Consumption
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BIOCHEMISTRY (2012)
Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1/PGC-1α signaling pathway
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BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2012)
Protein Misfolded Oligomers: Experimental Approaches, Mechanism of Formation, and Structure-Toxicity Relationships
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CHEMISTRY & BIOLOGY (2012)
Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation
Igor F. Tsigelny et al.
FEBS JOURNAL (2012)
Conformational Differences between Two Amyloid β Oligomers of Similar Size and Dissimilar Toxicity
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JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, and Escherichia coli Exists Predominantly as Disordered Monomer
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JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Structural Properties of EGCG-Induced, Nontoxic Alzheimer's Disease Aβ Oligomers
Juan Miguel Lopez del Amo et al.
JOURNAL OF MOLECULAR BIOLOGY (2012)
Epigallocatechin-3-Gallate as a Potential Therapeutic Drug for TTR-Related Amyloidosis: In Vivo Evidence from FAP Mice Models
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PLOS ONE (2012)
Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds
Mario Caruana et al.
FEBS LETTERS (2011)
α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
Tim Bartels et al.
NATURE (2011)
The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease
Sergio T. Ferreira et al.
NEUROBIOLOGY OF LEARNING AND MEMORY (2011)
In vivo demonstration that α-synuclein oligomers are toxic
Beate Winner et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
ANS Binding Reveals Common Features of Cytotoxic Amyloid Species
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ACS CHEMICAL BIOLOGY (2010)
Effects of epigallocatechin gallate on rotenone-injured murine brain cultures
Rudolf Moldzio et al.
JOURNAL OF NEURAL TRANSMISSION (2010)
(-)-Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, reduces dichlorodiphenyl-trichloroethane (DDT)-induced cell death in dopaminergic SHSY-5Y cells
Kwok-Keung Tai et al.
NEUROSCIENCE LETTERS (2010)
EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity
Jan Bieschke et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Neuroprotective effect of epigallocatechin-3-gallate against β-amyloid-induced oxidative and nitrosative cell death via augmentation of antioxidant defense capacity
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ARCHIVES OF PHARMACAL RESEARCH (2009)
Neuroprotective Effects of (-)-Epigallocatechin-3-gallate on Aging Mice Induced by D-Galactose
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BIOLOGICAL & PHARMACEUTICAL BULLETIN (2009)
(-)-Epigallocatechin-3-gallate prevents lipopolysaccharide-induced elevation of beta-amyloid generation and memory deficiency
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BRAIN RESEARCH (2009)
Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity
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FEBS LETTERS (2009)
Effect of lycopene and epigallocatechin-3-gallate against 3-nitropropionic acid induced cognitive dysfunction and glutathione depletion in rat: A novel nitric oxide mechanism
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FOOD AND CHEMICAL TOXICOLOGY (2009)
(-)-Epigallocatechin-3-Gallate Protects SH-SY5Y Cells Against 6-OHDA-Induced Cell Death through STAT3 Activation
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JOURNAL OF ALZHEIMERS DISEASE (2009)
Green Tea (-)-Epigallocatechin-3-Gallate Inhibits β-Amyloid-Induced Cognitive Dysfunction through Modification of Secretase Activity via Inhibition of ERK and NF-κB Pathways in Mice
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JOURNAL OF NUTRITION (2009)
Epigallocatechin gallate (EGCG) suppresses beta-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3 beta activation
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NEUROBIOLOGY OF AGING (2009)
Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation
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NEUROTOXICOLOGY (2009)
Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice
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BRAIN RESEARCH (2008)
Neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) on paraquat-induced apoptosis in PC12 cells
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CELL BIOLOGY INTERNATIONAL (2008)
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
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NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation
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NEUROREPORT (2008)
Early kinetics of amyloid fibril formation reveals conformational reorganisation of initial aggregates
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JOURNAL OF MOLECULAR BIOLOGY (2007)
Neuroprotective effects of (-)-epigallocatechin-3-gallate in a transgenic mouse model of amyotrophic lateral sclerosis
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NEUROCHEMICAL RESEARCH (2006)
Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models
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HUMAN MOLECULAR GENETICS (2006)
The effect of epigallocatechin gallate on suppressing disease progression of ALS model mice
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NEUROSCIENCE LETTERS (2006)
Stability of tea polyphenol (-)-epigallocatechin-3-gallate and formation of dimers and epimers under common experimental conditions
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2005)
Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice
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JOURNAL OF NEUROSCIENCE (2005)
Unfolding the role of protein misfolding in neurodegenerative diseases
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NATURE REVIEWS NEUROSCIENCE (2003)
α-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils
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JOURNAL OF MOLECULAR BIOLOGY (2002)
Prevention of nitric oxide-mediated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease in mice by tea phenolic epigallocatechin 3-gallate
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NEUROTOXICOLOGY (2002)
Oxidative stress increases expression and activity of BACE in NT2 neurons
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NEUROBIOLOGY OF DISEASE (2002)
Neurodegenerative disease - Amyloid pores from pathogenic mutations
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NATURE (2002)
The green tea polyphenol (-)-epigallocatechin gallate attenuates β-amyloid-induced neurotoxicity in cultured hippocampal neurons
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LIFE SCIENCES (2001)
Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration
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JOURNAL OF NEUROCHEMISTRY (2001)
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
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NATURE NEUROSCIENCE (2000)
Review:: Alzheimer's amyloid β-peptide-associated free radical oxidative stress and neurotoxicity
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JOURNAL OF STRUCTURAL BIOLOGY (2000)