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注意：仅列出部分参考文献，下载原文获取全部文献信息。CADASIL from Bench to Bedside: Disease Models and Novel Therapeutic Approaches
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Clinical and Genetic Aspects of CADASIL
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Notch signaling induces a transcriptionally permissive state at the Complement C3d Receptor 2 (CR2) promoter in a pre-B cell model
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MOLECULAR IMMUNOLOGY (2020)
The many facets of Notch signaling in breast cancer: toward overcoming therapeutic resistance
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GENES & DEVELOPMENT (2020)
Do as I say, Not(ch) as I do: Lateral control of cell fate
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Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques
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MOLECULAR CELL (2019)
Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL
Luca Tottone et al.
FRONTIERS IN ONCOLOGY (2019)
Delta-like 1-mediated cis-inhibition of Jagged1/2 signalling inhibits differentiation of human epidermal cells in culture
Victor A. Negri et al.
SCIENTIFIC REPORTS (2019)
Notch Signaling Activation as a Hallmark for Triple-Negative Breast Cancer Subtype
M. V. Giuli et al.
JOURNAL OF ONCOLOGY (2019)
Cis-activation in the Notch signaling pathway
Nagarajan Nandagopal et al.
ELIFE (2019)
Notch after cleavage
Sarah J. Bray et al.
CURRENT OPINION IN CELL BIOLOGY (2018)
Systematic Review: The Epidemiology, Natural History, and Burden of Alagille Syndrome
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JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2018)
Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells
Marica Pinazza et al.
ONCOGENE (2018)
NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence
Aled J. Parry et al.
NATURE COMMUNICATIONS (2018)
Drug Resistance in Non-Small Cell Lung Cancer: A Potential for NOTCH Targeting?
Venus Sosa Iglesias et al.
FRONTIERS IN ONCOLOGY (2018)
IL-4-dependent Jagged1 expression/processing is associated with survival of chronic lymphocytic leukemia cells but not with Notch activation
Filomena De Falco et al.
CELL DEATH & DISEASE (2018)
Notch: an interactive player in neurogenesis and disease
Runrui Zhang et al.
CELL AND TISSUE RESEARCH (2018)
Clinical and diagnostic relevance of NOTCH2 and KLF2 mutations in splenic marginal zone lymphoma
Yolanda Campos-Martin et al.
HAEMATOLOGICA (2017)
Both Notch1 and its ligands in B cells promote antibody production
Gaizhi Zhu et al.
MOLECULAR IMMUNOLOGY (2017)
NOTCH SIGNALING IN DEVELOPMENT, TISSUE HOMEOSTASIS, AND DISEASE
Chris Siebel et al.
PHYSIOLOGICAL REVIEWS (2017)
A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas
Russell J. H. Ryan et al.
CELL REPORTS (2017)
Clinical and diagnostic relevance of NOTCH2 and KLF2 mutations in splenic marginal zone lymphoma
Yolanda Campos-Martin et al.
HAEMATOLOGICA (2017)
Dynamic chromatin regulation at Notch target genes
Benedetto Daniele Giaimo et al.
TRANSCRIPTION-AUSTIN (2017)
The developmental biology of genetic Notch disorders
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DEVELOPMENT (2017)
The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force
Rhett A. Kovall et al.
DEVELOPMENTAL CELL (2017)
The Notch pathway in colorectal cancer
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INTERNATIONAL JOURNAL OF CANCER (2016)
NOTCH1 mediates a switch between two distinct secretomes during senescence
Matthew Hoare et al.
NATURE CELL BIOLOGY (2016)
Notch signalling in context
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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche
Michela Colombo et al.
ONCOTARGET (2016)
Transmission of survival signals through Delta-like 1 on activated CD4+ T cells
Takahiro Furukawa et al.
SCIENTIFIC REPORTS (2016)
Heterozygous Loss-of-Function Mutations in DLL4 Cause Adams-Oliver Syndrome
Josephina A. N. Meester et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2015)
Jagged1 intracellular domain-mediated inhibition of Notch1 signalling regulates cardiac homeostasis in the postnatal heart
Melanie Metrich et al.
CARDIOVASCULAR RESEARCH (2015)
Haploinsufficiency of the NOTCH1 Receptor as a Cause of Adams-Oliver Syndrome With Variable Cardiac Anomalies
Laura Southgate et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2015)
Structural basis for Notch1 engagement of Delta-like 4
Vincent C. Luca et al.
SCIENCE (2015)
Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL
Filomena De Falco et al.
Oncotarget (2015)
Haploinsufficiency of the NOTCH1 Receptor as a Cause of Adams-Oliver Syndrome With Variable Cardiac Anomalies
Laura Southgate et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2015)
Notcning on cancer's door: Notch signaling in brain tumors
Marcin Teodorczyk et al.
FRONTIERS IN ONCOLOGY (2015)
The NOTCH pathway is recurrently mutated in diffuse large B-cell lymphoma associated with hepatitis C virus infection
Luca Arcaini et al.
HAEMATOLOGICA (2015)
Mutations in NOTCH1 Cause Adams-Oliver Syndrome
Anna-Barbara Stittrich et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2014)
Notch4 reveals a novel mechanism regulating Notch signal transduction
A. C. James et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)
Hajdu-Cheney syndrome: a review
Ernesto Canalis et al.
ORPHANET JOURNAL OF RARE DISEASES (2014)
Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia
Yumi Yashiro-Ohtani et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Notch3/Jagged1 Circuitry Reinforces Notch Signaling and Sustains T-ALL
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NEOPLASIA (2014)
RBPJ Mutations Identified in Two Families Affected by Adams-Oliver Syndrome
Susan J. Hassed et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2012)
The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development
Davide Rossi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Whole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma
Mark J. Kiel et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
NOTCH2 mutations in Alagille syndrome
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JOURNAL OF MEDICAL GENETICS (2012)
Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy
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BLOOD CANCER JOURNAL (2012)
Mechanism and Significance of cis-Inhibition in Notch Signalling
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CURRENT BIOLOGY (2011)
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DEVELOPMENT (2011)
Serpentine Fibula-Polycystic Kidney Syndrome Caused by Truncating Mutations in NOTCH2
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HUMAN MUTATION (2011)
Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis
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NATURE GENETICS (2011)
Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss
Michael A. Simpson et al.
NATURE GENETICS (2011)
Notch1 signaling is mediated by importins alpha 3, 4, and 7
Kerstin Huenniger et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2010)
Cis-interactions between Notch and Delta generate mutually exclusive signalling states
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NATURE (2010)
Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells
Emanuela Rosati et al.
BLOOD (2009)
Deletion of Notch1 Converts Pro-T Cells to Dendritic Cells and Promotes Thymic B Cells by Cell-Extrinsic and Cell-intrinsic Mechanisms
Thorsten B. Feyerabend et al.
IMMUNITY (2009)
Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage
Geert van Tetering et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Notch Ligands Expressed by Follicular Dendritic Cells Protect Germinal Center B Cells from Apoptosis
Sun-Ok Yoon et al.
JOURNAL OF IMMUNOLOGY (2009)
Mutation of HAIRY-AND-ENHANCER-OF-SPLIT-7 in humans causes spondylocostal dysostosis
Duncan B. Sparrow et al.
HUMAN MOLECULAR GENETICS (2008)
Expression of Delta-like 1 in the splenic non-hematopoietic cells is essential for marginal zone B cell development
Yin Sheng et al.
IMMUNOLOGY LETTERS (2008)
A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition
Jemima Cordle et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy
Yulia Nefedova et al.
BLOOD (2008)
Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1
Shinji Tagami et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
The transcriptional coactivator Mam11 is required for Notch2-mediated marginal zone B-cell development
Lizi Wu et al.
BLOOD (2007)
Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells
Margarida Almeida Santos et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo
Toshinao Oyama et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Notch activity synergizes with B-cell-receptor and CD40 signaling to enhance B-cell activation
Matthew Thomas et al.
BLOOD (2007)
Structural basis for autoinhibition of Notch
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NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
DSL ligand endocytosis physically dissociates Notch 1 heterodimers before activating proteolysis can occur
James T. Nichols et al.
JOURNAL OF CELL BIOLOGY (2007)
The Delta intracellular domain mediates TGF-β/Activin signaling through binding to Smads and has an important bi-directional function in the Notch-Delta signaling pathway
Masahiro Hiratochi et al.
NUCLEIC ACIDS RESEARCH (2007)
NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway
Ryan McDaniell et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2006)
Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype
DB Sparrow et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2006)
Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance
AW Duncan et al.
NATURE IMMUNOLOGY (2005)
Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA
RA Kovall et al.
EMBO JOURNAL (2004)
Structural and functional properties of the human Notch-1 ligand binding region
S Hambleton et al.
STRUCTURE (2004)
Notch3 is required for arterial identity and maturation of vascular smooth muscle cells
V Domenga et al.
GENES & DEVELOPMENT (2004)
Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development
NW Gale et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Mutated MESP2 causes spondylocostal dysostosis in humans
NV Whittock et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2004)
Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo
K Hozumi et al.
NATURE IMMUNOLOGY (2004)
Constitutively active Notch4 promotes early human hematopoietic progenitor cell maintenance while inhibiting differentiation and causes lymphoid abnormalities in vivo
SM Vercauteren et al.
BLOOD (2004)
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
LT Krebs et al.
GENES & DEVELOPMENT (2004)
Dosage-sensitive requirement for mouse D114 in artery development
A Duarte et al.
GENES & DEVELOPMENT (2004)
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
AP Weng et al.
SCIENCE (2004)
Notch2 haploinsufficiency results in diminished B1B cells and a severe reduction in marginal zone B cells
CM Witt et al.
JOURNAL OF IMMUNOLOGY (2003)
The Notch ligands, Jagged and Delta, are sequentially processed by α-secretase and presenilin/γ-secretase and release signaling fragments
MJ LaVoie et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase
E Six et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Novel mutations in DLL3, a somitogenesis gene encoding a ligand for the Notch signalling pathway, cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis
PD Turnpenny et al.
JOURNAL OF MEDICAL GENETICS (2003)
Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development
T Saito et al.
IMMUNITY (2003)
The notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent γ-secretase cleavage
T Ikeuchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Activated Notch2 potentiates CD8 lineage maturation and promotes the selective development of B1B cells
CM Witt et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Characterization of Notch3-deficient mice: Normal embryonic development and absence of genetic interactions with a Notch1 mutation
LT Krebs et al.
GENESIS (2003)
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for α-secretase activity in fibroblasts
D Hartmann et al.
HUMAN MOLECULAR GENETICS (2002)
Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision
H Han et al.
INTERNATIONAL IMMUNOLOGY (2002)
Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations
S Kawamata et al.
ONCOGENE (2002)
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells
K Tanigakik et al.
NATURE IMMUNOLOGY (2002)
Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome
S Stier et al.
BLOOD (2002)
Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression
K Kumano et al.
BLOOD (2001)
Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus
A Wilson et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2001)
MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors
LZ Wu et al.
NATURE GENETICS (2000)
Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells
FE Bertrand et al.
LEUKEMIA (2000)
Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling
B Varnum-Finney et al.
NATURE MEDICINE (2000)
Mastermind is a putative activator for Notch
AG Petcherski et al.
CURRENT BIOLOGY (2000)
Mutations in the human Delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis
MP Bulman et al.
NATURE GENETICS (2000)
A novel proteolytic cleavage involved in Notch signaling:: The role of the disintegrin-metalloprotease TACE
C Brou et al.
MOLECULAR CELL (2000)
A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1
JS Mumm et al.
MOLECULAR CELL (2000)
A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells
W Han et al.
BLOOD (2000)
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