期刊
BIOMOLECULES
卷 11, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/biom11071045
关键词
leptin; leptin receptor; leptin-activity modulators; peptide antagonists; leptin mutants; monoclonal antibodies; nanobodies
资金
- European Union
- MIUR
- European Social Fund-PON RI 2014-2020
Leptin, a multifunctional hormone primarily produced in adipose tissue, plays a crucial role in regulating various biological functions through interaction with its receptor. Abnormal levels of leptin and leptin resistance are associated with different diseases, suggesting the potential of developing leptin signaling modulators for treatment.
Leptin, a multifunctional hormone primarily, but not exclusively, secreted in adipose tissue, is implicated in a wide range of biological functions that control different processes, such as the regulation of body weight and energy expenditure, reproductive function, immune response, and bone metabolism. In addition, leptin can exert angiogenic and mitogenic actions in peripheral organs. Leptin biological activities are greatly related to its interaction with the leptin receptor. Both leptin excess and leptin deficiency, as well as leptin resistance, are correlated with different human pathologies, such as autoimmune diseases and cancers, making leptin and leptin receptor important drug targets. The development of leptin signaling modulators represents a promising strategy for the treatment of cancers and other leptin-related diseases. In the present manuscript, we provide an update review about leptin-activity modulators, comprising leptin mutants, peptide-based leptin modulators, as well as leptin and leptin receptor specific monoclonal antibodies and nanobodies.
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