Retinal Dysfunction in Alzheimer's Disease and Implications for Biomarkers

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that manifests as cognitive deficits and memory decline, especially in old age. Several biomarkers have been developed to monitor AD progression. Given that the retina and brain share some similarities including features related to anatomical composition and neurological functions, the retina is closely associated with the progression of AD. Herein, we review the evidence of retinal dysfunction in AD, particularly at the early stage, together with the underlying molecular mechanisms. Furthermore, we compared the retinal pathologies of AD and other ophthalmological diseases and summarized potential retinal biomarkers measurable by existing technologies for detecting AD, providing insights for the future development of diagnostic tools.

Automated summary

Alzheimer's disease is a progressive neurodegenerative disorder that commonly affects the elderly, with the retina closely associated with its progression through dysfunction and molecular mechanisms. Research on retinal pathologies and biomarkers measurable by existing technologies provide insights for future diagnostic tool development for AD.