期刊
BIOMOLECULES
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/biom11091289
关键词
gold nanoparticles; autoimmune diseases; immunomodulatory effects; nanomedicine
资金
- Russian Science Foundation [18-15-00254]
Gold nanoparticles have unique properties that make them ideal for research in bio-nanotechnology, with their ease of synthesis, stability, high drug-loading capacity, and biocompatibility. They have the potential to manage various autoimmune disorders by modulating toxicity, biodistribution, biocompatibility, and effects.
Gold nanoparticles (GNPs) have been recently applied for various diagnostic and therapeutic purposes. The unique properties of these nanoparticles (NPs), such as relative ease of synthesis in various sizes, shapes and charges, stability, high drug-loading capacity and relative availability for modification accompanied by non-cytotoxicity and biocompatibility, make them an ideal field of research in bio-nanotechnology. Moreover, their potential to alleviate various inflammatory factors, nitrite species, and reactive oxygen production and the capacity to deliver therapeutic agents has attracted attention for further studies in inflammatory and autoimmune disorders. Furthermore, the characteristics of GNPs and surface modification can modulate their toxicity, biodistribution, biocompatibility, and effects. This review discusses in vitro and in vivo effects of GNPs and their functionalized forms in managing various autoimmune disorders (Ads) such as rheumatoid arthritis, type 1 diabetes, and multiple sclerosis.
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