期刊
BIOMOLECULES
卷 11, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/biom11070928
关键词
systemic lupus erythematosus; biomarkers; diagnosis; monitoring; omics
资金
- National Natural Science Foundation of China [81960388]
- Longyuan Youth Innovation and Entrepreneurship Talents (Organization Department of Gansu Province) [9]
- Natural Science Foundation of Gansu Province [20JR5RA367]
- Science and Technology Plan Project of Chengguan District Lanzhou City [2020-2-11-3]
- GSK Japan Research Grant 2020
Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease characterized by immune dysfunction. Clinical and immunological biomarkers are crucial for diagnosing, assessing, and controlling SLE, including novel biomarkers discovered through omics research.
Systemic lupus erythematosus (SLE) is characterized by immune system dysfunction and is clinically heterogeneous, exhibiting renal, dermatological, neuropsychiatric, and cardiovascular symptoms. Clinical and physiological assessment is usually inadequate for diagnosing and assessing pathophysiological processes in SLE. Clinical and immunological biomarkers could play a critical role in improving diagnosis, assessment, and ultimately, control of SLE. This article reviews clinical and immunological biomarkers that could diagnose and monitor disease activity in SLE, with and without organ-specific injury. In addition, novel SLE biomarkers that have been discovered through omics research are also reviewed.
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