期刊
BIOMOLECULES
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/biom11091282
关键词
comparative genomics; metabolic reconstruction; bioinformatics; conserved unknowns; function prediction; functional annotation; orthology
资金
- National Institutes of Health [GM70641]
- University of Florida Dept of Microbiology and Cell Sciences
Members of the DUF34 family, also known as the NIF3 protein superfamily, have been widely annotated as GTP cyclohydrolase I type 2, but new research suggests they may serve as metal ion insertases, chaperones, or metallocofactor maturases. This diverse molecular function could explain their involvement in pathways such as cell differentiation, metal ion homeostasis, pathogen virulence, redox, and universal stress responses.
Members of the DUF34 (domain of unknown function 34) family, also known as the NIF3 protein superfamily, are ubiquitous across superkingdoms. Proteins of this family have been widely annotated as GTP cyclohydrolase I type 2 through electronic propagation based on one study. Here, the annotation status of this protein family was examined through a comprehensive literature review and integrative bioinformatic analyses that revealed varied pleiotropic associations and phenotypes. This analysis combined with functional complementation studies strongly challenges the current annotation and suggests that DUF34 family members may serve as metal ion insertases, chaperones, or metallocofactor maturases. This general molecular function could explain how DUF34 subgroups participate in highly diversified pathways such as cell differentiation, metal ion homeostasis, pathogen virulence, redox, and universal stress responses.
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