期刊
BIOMOLECULES
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/biom11091265
关键词
breast cancer; PITPNM1; proliferation; metastasis
资金
- National Key R&D Program of China [2017YFC1309103, 2017YFC1309104]
- Natural Science Foundation of China [81672594, 81772836, 81872139, 82072907]
- Clinical Innovation Project of Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) [2018GZR0201004]
- Sun Yat-sen memorial hospital cultivation project for clinical research [SYS-C-201805]
- Key Projects of The National Natural Science Foundation of China [51861125203]
- Beijing Xisike Clinical Oncology Research Foundation [YRoche2019/2-0078]
- Technology Development Program of Guangdong province [2021A0505030082]
- Project of The Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation [2020B1212060018OF007]
PITPNM1 plays a crucial role in the progression of breast cancer, with its high expression associated with poor prognosis and involvement in carcinogenesis and cell signaling.
Phosphatidylinositol transfer protein membrane-associated 1 (PITPNM1) contains a highly conserved phosphatidylinositol transfer domain which is involved in phosphoinositide trafficking and signaling transduction under physiological conditions. However, the functional role of PITPNM1 in cancer progression remains unknown. Here, by integrating datasets of The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer (METABRIC), we found that the expression of PITPNM1 is much higher in breast cancer tissues than in normal breast tissues, and a high expression of PITPNM1 predicts a poor prognosis for breast cancer patients. Through gene set variation analysis (GSEA) and gene ontology (GO) analysis, we found PITPNM1 is mainly associated with carcinogenesis and cell-to-cell signaling ontology. Silencing of PITPNM1, in vitro, significantly abrogates proliferation and colony formation of breast cancer cells. Collectively, PITPNM1 is an important prognostic indicator and a potential therapeutic target for breast cancer.
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