4.7 Review

Beyond the GFAP-Astrocyte Protein Markers in the Brain

期刊

BIOMOLECULES
卷 11, 期 9, 页码 -

出版社

MDPI
DOI: 10.3390/biom11091361

关键词

astroglia; reactive astrogliosis; astrocyte reactivity; astrocyte phenotype; astrocyte state; protein markers

资金

  1. National Science Centre [OPUS14 2017/27/B/NZ7/00289]
  2. Maj Institute of Pharmacology, Polish Academy of Sciences

向作者/读者索取更多资源

This review discusses the crucial communication between neurons and neuroglia for functional efficiency and quick response to danger. It focuses on identifying markers for different astroglial phenotypes related to various physiological and pathological conditions, aiming to facilitate future experimental studies and diagnostics.
The idea of central nervous system as one-man band favoring neurons is long gone. Now we all are aware that neurons and neuroglia are team players and constant communication between those various cell types is essential to maintain functional efficiency and a quick response to danger. Here, we summarize and discuss known and new markers of astroglial multiple functions, their natural heterogeneity, cellular interactions, aging and disease-induced dysfunctions. This review is focused on newly reported facts regarding astrocytes, which are beyond the old stereotypes. We present an up-to-date list of marker proteins used to identify a broad spectrum of astroglial phenotypes related to the various physiological and pathological nervous system conditions. The aim of this review is to help choose markers that are well-tailored for specific needs of further experimental studies, precisely recognizing differential glial phenotypes, or for diagnostic purposes. We hope it will help to categorize the functional and structural diversity of the astroglial population and ease a clear readout of future experimental results.

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