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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Entry of oximes into the brain: A review
D. E. Lorke et al.
CURRENT MEDICINAL CHEMISTRY (2008)
Recent developments in the chemistry and in the biological applications of amidoximes
K. C. Fylaktakidou et al.
CURRENT PHARMACEUTICAL DESIGN (2008)
2-Amino-5-thiazolyl motif: A novel scaffold for designing anti-inflammatory agents of diverse structures
P. X. Franklin et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2008)
Wnt/β-catenin signaling controls development of the blood-brain barrier
Stefan Liebner et al.
JOURNAL OF CELL BIOLOGY (2008)
Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin
Kai Kessenbrock et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Soluble 3′,6-Substituted Indirubins with Enhanced Selectivity toward Glycogen Synthase Kinase-3 Alter Circadian Period
Konstantina Vougogiannopoulou et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Blood-brain barrier tight junction permeability and ischemic stroke
Karin E. Sandoval et al.
NEUROBIOLOGY OF DISEASE (2008)
Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors
Stuart L. Emanuel et al.
MOLECULAR PHARMACOLOGY (2008)
A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition
Matt Petrus et al.
MOLECULAR PAIN (2007)
Vasorelaxant activity of some oxime derivatives
Filip Jaros et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2007)
Microglia: active sensor and versatile effector cells in the normal and pathologic brain
Uwe-Karsten Hanisch et al.
NATURE NEUROSCIENCE (2007)
An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins
Vassilios Myrianthopoulos et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis
Thierry Bordet et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
Inflammation and metabolic disorders
Goekhan S. Hotamisligil
NATURE (2006)
Diacetyldiamidoximeester of pentamidine, a prodrug for treatment of protozoal diseases:: Synthesis, in vitro and in vivo biotransformation
Bernd Clement et al.
CHEMMEDCHEM (2006)
7-bromoindirubin-3′-oxime induces caspase-independent cell death
J. Ribas et al.
ONCOGENE (2006)
Synthesis, ocular effects, and nitric oxide donation of imidazole amidoximes
L. Oresmaa et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2006)
Identification of chemically diverse Chk1 inhibitors by receptor-based virtual screening
Nicolas Foloppe et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Synthesis, cytotoxicity, and anti-inflammatory evaluation of 2-(furan-2-yl)-4-(phenoxy)quinoline derivatives. Part 4
Yeh-Long Chen et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
In silico identification of novel EGFR inhibitors with antiproliferative activity against cancer cells
CN Cavasotto et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, has highly potent antitumor activity against established tumors
N Amino et al.
CLINICAL CANCER RESEARCH (2006)
The identification of potent and selective imidazole-based inhibitors of B-Raf kinase
AK Takle et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Synthesis and structure-activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities
MJ Moon et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Cancer stem cells and therapeutic perspectives
E Galmozzi et al.
CURRENT MEDICINAL CHEMISTRY (2006)
Indirubin-3′-monoxime, a derivative of a Chinese antileukemia medicine, inhibits P-TEFb function and HIV-1 replication
A Heredia et al.
AIDS (2005)
Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3
M Martin et al.
NATURE IMMUNOLOGY (2005)
ATP mediates rapid microglial response to local brain injury in vivo
D Davalos et al.
NATURE NEUROSCIENCE (2005)
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
A Nimmerjahn et al.
SCIENCE (2005)
Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells
S Nam et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Effects of dialkoxylphenyl compounds with oxime group on macrophage function and the proliferation of lymphocytes
ES Yoo et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2004)
Relaxant effect of oxime derivatives in isolated rat aorta: role of nitric oxide (NO) formation in smooth muscle
K Chalupsky et al.
BIOCHEMICAL PHARMACOLOGY (2004)
Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential
MA Bogoyevitch et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2004)
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases
P Polychronopoulos et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Synthesis and anti-inflammatory evaluation of 4-anilinofuro[2,3-b]quinoline and 4-phenoxyfuro[2,3-b]quinoline derivatives.: Part 3
YL Chen et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2004)
Design, synthesis, and SAR studies of some 5-aliphatic oximino esters of thiophene as potential anti-inflammatory leads: comparative biological activity profile of aliphatic oximes vs aromatic oximes
AD Pillai et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Synthesis and antitumor activity of novel O-carbamoylmethyloxime derivatives of radicicol
Y Ikuina et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry
F Tsamis et al.
JOURNAL OF VIROLOGY (2003)
GSK-3-selective inhibitors derived from Tyrian purple indirubins
L Meijer et al.
CHEMISTRY & BIOLOGY (2003)
Nitric oxide-donating nonsteroidal anti-inflammatory drugs inhibit the growth of various cultured human cancer cells: Evidence of a tissue type-independent effect
K Kashfi et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Involvement of NO in the endothelium-independent relaxing effects of Nω-Hydroxy-L-arginine and other compounds bearing a C=NOH function in the rat aorta
P Vetrovsky et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Activation of spinal kainate receptors after inflammation: behavioral hyperalgesia and subunit gene expression
W Guo et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2002)
Indirubin and meisoindigo in the treatment of chronic myelogenous leukemia in China
ZJ Xiao et al.
LEUKEMIA & LYMPHOMA (2002)
A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1α and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts
J Kurebayashi et al.
JAPANESE JOURNAL OF CANCER RESEARCH (2001)
SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo
JM Strizki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Oxidation of the ketoxime acetoxime to nitric oxide by oxygen radical-generating systems
AA Caro et al.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2001)
Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells
D Marko et al.
BRITISH JOURNAL OF CANCER (2001)
Indirubins inhibit glycogen synthase kinase-3β and CDK5/P25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease -: A property common to most cycline-dependent kinase inhibitors?
S Leclerc et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
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