期刊
BIOMOLECULES
卷 11, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/biom11060853
关键词
breast cancer; cholesteryl ester; SOAT1; avasimibe
资金
- National Key Research and Development Program of China [2017YFD0400200]
- National Natural Science Foundation of China [31771539]
- Key Research and Development Program of Jiangsu Province [BE2018624]
- National First-class Discipline Program of Food Science and Technology [JUFSTR20180101]
The study found that CE can promote mammary tumor growth by upregulating the AKT/mTOR pathway, and blocking CE synthesis can suppress this signaling pathway, suggesting that SOAT1 may be a potential target for the treatment of breast cancer.
The association between intratumoral cholesteryl ester (CE) and tumor progression has been reported previously. The objective of our study was to investigate a causal effect of CE on mammary tumor progression. Using MMTV-PyMT (MMTV-polyoma virus middle T) transgenic mice and breast tumor cell MCF-7, we show that both exogenous and endogenous CE can increase mammary tumor growth, that CE upregulates the AKT/mTOR pathway, and that CE synthesis blockade suppresses this signaling pathway. Our data suggest that SOAT1, a sterol O-acyltransferase, may be a potential target for the treatment of breast cancer.
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