☆ 4.7 Article

Influenza Virus-like Particle (VLP) Vaccines Expressing the SARS-CoV-2 S Glycoprotein, S1, or S2 Domains

VACCINES (2021)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Chemistry, Multidisciplinary

Biomimetic Virus-Like Particles as Severe Acute Respiratory Syndrome Coronavirus 2 Diagnostic Tools

Soo Khim Chan et al.

Summary: COVID-19 is a highly transmissible disease affecting majority of countries globally. The use of nucleic acid tests, especially RT-PCR, has become essential for early detection of infection. Generating biomimetic virus-like particles as positive controls can overcome the need for cold-chain distribution, providing reliable, scalable, and stable controls for clinical settings.

ACS NANO (2021)

添加到收藏夹

Letter Infectious Diseases

Emergence of a new SARS-CoV-2 variant in the UK

Julian W. Tang et al.

JOURNAL OF INFECTION (2021)

添加到收藏夹

Article Virology

A stable platform for the production of virus-like particles pseudotyped with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein

Sylvie Roy et al.

Summary: The codon optimized S protein of SARS-CoV-2 can migrate to the cell membrane. Efficient production of MLV infectious viral particles was achieved with stable expression of a shorter Delta S version. Delta S was 15-times more efficiently incorporated into VLPs compared to S, showing potential for immunization strategies for COVID-19.

VIRUS RESEARCH (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

Tiong Kit Tan et al.

Summary: This study introduces a potential vaccine candidate against SARS-CoV-2, utilizing a synthetic virus-like particle platform to present the receptor-binding domain of the virus spike protein. The vaccine induces strong neutralizing antibody responses in mice and pigs, demonstrating thermostability and the potential for global distribution.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Public, Environmental & Occupational Health

Emergence of SARS-CoV-2 B.1.1.7 Lineage — United States, December 29, 2020–January 12, 2021

Summer E. Galloway et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

添加到收藏夹

Article Immunology

Newcastle Disease Virus-Like Particles Displaying Prefusion-Stabilized SARS-CoV-2 Spikes Elicit Potent Neutralizing Responses

Yongping Yang et al.

Summary: This study reports the development of a COVID-19 vaccine using NDVLP displaying the SARS-CoV-2 spike, which showed good antigenicity and morphology, as well as higher neutralizing ability in mice compared to soluble S2P. These findings suggest that S2P-NDVLP could be a promising candidate for an effective COVID-19 vaccine.

VACCINES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection

Elizabeth M. Anderson et al.

Summary: Our research indicates that most individuals had antibodies against other seasonal human coronaviruses before the COVID-19 pandemic. Around 20% of these individuals also had antibodies that cross-reacted with SARS-CoV-2, but these antibodies did not offer protection against SARS-CoV-2 infections or hospitalizations.

CELL (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Immunogenicity and inflammatory properties of respiratory syncytial virus attachment G protein in cotton rats

Margaret E. Martinez et al.

Summary: The RSV G protein can mimic a cytokine and cause increased pulmonary inflammation by binding to immune cells, but blocking the G protein may reduce inflammation due to reduced virus replication and spread instead of its role as a viral chemokine. Expressing the G protein in cotton rat lungs did not increase inflammation but did induce immune responses and partial protection against RSV, with complete protection achieved through co-immunization with interferon alpha.

PLOS ONE (2021)

添加到收藏夹

Article Microbiology

Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model

Ericka Kirkpatrick Roubidoux et al.

Summary: Current seasonal influenza virus vaccines targeting regions of the hemagglutinin head domain undergo constant antigenic change, necessitating annual reformulation. Broadly protective or universal influenza virus vaccines targeting the HA stalk domain have potential to provide cross-reactive immune responses. Understanding antigenic drift in the HA stalk domain is crucial for vaccine development and effectiveness.

MBIO (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers

Saghi Nooraei et al.

Summary: Virus-like particles (VLPs) are virus-derived structures without genetic material, able to self-assemble and mimic viruses, utilized in candidate vaccines and successful applications in targeted drug delivery and gene therapy. Modifying the surface of VLPs for increased specificity and longevity in specific cells or tissues may enhance their future use.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

添加到收藏夹

Article Immunology

Evaluation of Cellular and Serological Responses to Acute SARS-CoV-2 Infection Demonstrates the Functional Importance of the Receptor-Binding Domain

Grace Mantus et al.

Summary: This study provides a cross-sectional analysis of B cell responses to SARS-CoV-2 infection in hospitalized COVID-19 patients, showing changes in B cell subsets consistent with a robust humoral immune response. Elevated levels of Abs to SARS-CoV-2 RBD were observed during infection, with higher levels of RBD-specific IgG correlating with increased serum neutralization. The findings have implications for future vaccine design and monoclonal antibody strategies.

JOURNAL OF IMMUNOLOGY (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Immune response induced by oral administration with a Saccharomyces cerevisiae-based SARS-CoV-2 vaccine in mice

Tong Gao et al.

Summary: The global COVID-19 pandemic has highlighted the urgent need for vaccines, with several candidates under development. A Saccharomyces cerevisiae-based vaccine against SARS-CoV-2 showed significant immune responses in mice, indicating the potential for use as a universal technology platform for developing other oral viral or bacterial vaccines.

MICROBIAL CELL FACTORIES (2021)

添加到收藏夹

Article Medicine, General & Internal

Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant

S. A. Madhi et al.

Summary: The ChAdOx1 nCoV-19 vaccine did not provide significant protection against mild-to-moderate Covid-19 caused by the B.1.351 variant, with an efficacy of 10.4%. The incidence of serious adverse events was balanced between the vaccine and placebo groups.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

添加到收藏夹

Review Infectious Diseases

Status Report on COVID-19 Vaccines Development

Arun Kumar et al.

Summary: This review discusses the development of COVID-19 vaccines, including various types and efficacy. Recent findings of new variants suggest that current vaccines may need updates to combat these new strains.

CURRENT INFECTIOUS DISEASE REPORTS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2

Shion A. Lim et al.

Summary: The study shows that combining non-neutralizing RBD antibodies with neutralizing binders can significantly enhance the neutralization of SARS-CoV-2. This novel bispecific antibody engineering strategy holds promise as a rapid way to boost the potency of antibodies against the virus.

MABS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

添加到收藏夹

Article Medicine, General & Internal

A Novel Coronavirus from Patients with Pneumonia in China, 2019

Na Zhu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Microbiology

Infection and Rapid Transmission of SARS-CoV-2 in Ferrets

Young-Il Kim et al.

CELL HOST & MICROBE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Human neutralizing antibodies elicited by SARS-CoV-2 infection

Bin Ju et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

Jun Lan et al.

NATURE (2020)

添加到收藏夹

Article Cell Biology

Preliminary Trichinella spiralis Infection Ameliorates Subsequent RSV Infection-Induced Inflammatory Response

Ki-Back Chu et al.

CELLS (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Construction of SARS-CoV-2 Virus-Like Particles by Mammalian Expression System

Ruodan Xu et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2-spike protein-protein interaction

Chee Wah Tan et al.

NATURE BIOTECHNOLOGY (2020)

添加到收藏夹

Review Immunology

Animal and translational models of SARS-CoV-2 infection and COVID-19

M. D. Johansen et al.

MUCOSAL IMMUNOLOGY (2020)

添加到收藏夹

Editorial Material Biotechnology & Applied Microbiology

Evolution of the COVID-19 vaccine development landscape

Tung Thanh Le et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Role of antibody-dependent enhancement (ADE) in the virulence of SARS-CoV-2 and its mitigation strategies for the development of vaccines and immunotherapies to counter COVID-19

Kumaragurubaran Karthik et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2020)

添加到收藏夹

Article Medicine, General & Internal

Evaluating the Association of Clinical Characteristics With Neutralizing Antibody Levels in Patients Who Have Recovered From Mild COVID-19 in Shanghai, China

Fan Wu et al.

JAMA INTERNAL MEDICINE (2020)

添加到收藏夹

Article Virology

Antibody Binding to SARS-CoV-2 S Glycoprotein Correlates with but Does Not Predict Neutralization

Shilei Ding et al.

VIRUSES-BASEL (2020)

添加到收藏夹

Review Immunology

The trinity of COVID-19: immunity, inflammation and intervention

Matthew Zirui Tay et al.

NATURE REVIEWS IMMUNOLOGY (2020)

添加到收藏夹

Article Immunology

Generation of neutralizing and non-neutralizing monoclonal antibodies against H7N9 influenza virus

Fan Yang et al.

EMERGING MICROBES & INFECTIONS (2020)

添加到收藏夹

Review Virology

Coronavirus envelope protein: current knowledge

Dewald Schoeman et al.

VIROLOGY JOURNAL (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Influenza M2 virus-like particle vaccination enhances protection in combination with avian influenza HA VLPs

Hae-Ji Kang et al.

PLOS ONE (2019)

添加到收藏夹

Article Immunology

Immune Correlates of Protection Induced by Virus-Like Particles Containing 2009 H1N1 Pandemic Influenza HA, NA or M1 Proteins

Eun-Kyung Moon et al.

IMMUNOLOGICAL INVESTIGATIONS (2019)

添加到收藏夹

Article Virology

Broadly Cross-Reactive, Nonneutralizing Antibodies against Influenza B Virus Hemagglutinin Demonstrate Effector Function-Dependent Protection against Lethal Viral Challenge in Mice

Guha Asthagiri Arunkumar et al.

JOURNAL OF VIROLOGY (2019)

添加到收藏夹

Review Immunology

The human antibody response to influenza A virus infection and vaccination

Florian Krammer

NATURE REVIEWS IMMUNOLOGY (2019)

添加到收藏夹

Article Immunology

Simultaneous Targeting of Multiple Hemagglutinins to APCs for Induction of Broad Immunity against Influenza

Ane Marie Anderson et al.

JOURNAL OF IMMUNOLOGY (2018)

添加到收藏夹

Article Microbiology

An Improved Tobacco Mosaic Virus (TMV)-Conjugated Multiantigen Subunit Vaccine Against Respiratory Tularemia

Ahd A. Mansour et al.

FRONTIERS IN MICROBIOLOGY (2018)

添加到收藏夹

Article Immunology

Virus-like particle vaccines expressing Toxoplasma gondii rhoptry protein 18 and microneme protein 8 provide enhanced protection

Su-Hwa Lee et al.

VACCINE (2018)

添加到收藏夹

Review Immunology

The complexity and cost of vaccine manufacturing - An overview

Stanley Plotkin et al.

VACCINE (2017)

添加到收藏夹

Article Oncology

A multi-antigen vaccine in combination with an immunotoxin targeting tumor-associated fibroblast for treating murine melanoma

Jinxu Fang et al.

MOLECULAR THERAPY-ONCOLYTICS (2016)

添加到收藏夹

Article Virology

Assessment of Influenza Virus Hemagglutinin Stalk-Based Immunity in Ferrets

Florian Krammer et al.

JOURNAL OF VIROLOGY (2014)

添加到收藏夹

Article Virology

Hemagglutinin Stalk-Based Universal Vaccine Constructs Protect against Group 2 Influenza A Viruses

I. Margine et al.

JOURNAL OF VIROLOGY (2013)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Plant-derived virus-like particles as vaccines

Qiang Chen et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2013)

添加到收藏夹

Article Medicine, Research & Experimental

Neutralizing epitopes of the SARS-CoV S-protein cluster independent of repertoire, antigen structure or mAb technology

Jody D. Berry et al.

MABS (2010)

添加到收藏夹

Article Microbiology

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain

John Steel et al.

MBIO (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

Antibody-mediated synergy and interference in the neutralization of SARS-CoV at an epitope cluster on the spike protein

Lilin Zhong et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

添加到收藏夹

Article Virology

Incorporation of Membrane-Anchored Flagellin into Influenza Virus-Like Particles Enhances the Breadth of Immune Responses

Bao-Zhong Wang et al.

JOURNAL OF VIROLOGY (2008)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.