☆ 4.7 Review

Vaccination in PADs

VACCINES (2021)

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Article Allergy

Coronavirus disease 2019 in patients with inborn errors of immunity: An international study

Isabelle Meyts et al.

Summary: The study shows that patients with IEI exhibit varied responses to SARS-CoV-2 infection, with some requiring hospitalization and even intensive care, and a non-negligible mortality rate. In comparison to the general population, younger IEI patients may face a higher risk of severe illness and mortality.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Review Immunology

Clinical management of patients with primary immunodeficiencies during the COVID-19 pandemic

Isabella Quinti et al.

Summary: Patients with Inborn Errors of Immunity (IEI) have been considered a potential risk group during the COVID-19 pandemic. Surprisingly, the number of IEI patients affected by SARS-Cov-2 is low, with a mortality risk similar to that of the general population. Physicians implemented early safety measures, such as home therapy and remote assistance, which may have contributed to the low number of affected IEI patients. The guidelines issued by scientific societies are essential for the clinical management of IEI patients.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Jordan R. Barrett et al.

Summary: The study demonstrates that a booster dose of ChAdOx1 nCoV-19 is safer and better tolerated than priming doses. The booster dose significantly enhances anti-spike neutralizing antibody titers and other functional antibody responses. These data support the two-dose vaccine regime currently being evaluated in phase 3 clinical trials.

NATURE MEDICINE (2021)

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Article Multidisciplinary Sciences

Subcutaneous immunoglobulins replacement therapy in secondary antibody deficiencies: Real life evidence as compared to primary antibody deficiencies

Francesco Cinetto et al.

Summary: Evidence suggests that SCIG is equally effective in reducing infection rates in both SAD and PAD patients, with SAD patients requiring lower SCIG dosage and IgG levels to achieve similar effects. SCIG is also effective regardless of underlying diseases in SAD patients, with comparable treatment tolerance to PAD patients.

PLOS ONE (2021)

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Review Obstetrics & Gynecology

EBCOG position statement on COVID-19 vaccination for pregnant and breastfeeding women

Ines Martins et al.

Summary: The Covid 19 pandemic has resulted in a significant increase in mortality and morbidity globally, particularly affecting pregnant women who are at higher risk of severe illness. Urgent vaccination efforts are needed to protect all pregnant women, especially those with high-risk pregnancies.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2021)

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Article Immunology

Robust Antibody and T Cell Responses to SARS-CoV-2 in Patients with Antibody Deficiency

Hannah Kinoshita et al.

Summary: This study characterized antibody and T cell responses to SARS-CoV-2 structural proteins in patients with antibody deficiencies, showing robust T cell activity and humoral immunity in some patients. The study results are encouraging, especially considering the reliance on spike protein in most candidate vaccines, but further research is needed to define the timing of immunity onset, longevity of immune response, and variability in immunocompromised patients.

JOURNAL OF CLINICAL IMMUNOLOGY (2021)

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Article Immunology

Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee

Stuart G. Tangye et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2020)

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Article Allergy

Vaccines in Patients with Primary Immune Deficiency

Francisco A. Bonilla

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (2020)

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Article Immunology

IGA Antibody Induced by Immunization With Pneumococcal Polysaccharides Is a Prognostic Tool in Common Variable Immune Deficiencies

Federica Pulvirenti et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Allergy

Health-Related Quality of Life in Common Variable Immunodeficiency Italian Patients Switched to Remote Assistance the COVID-19 Pandemic

Federica Pulvirenti et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

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Review Biotechnology & Applied Microbiology

mRNA vaccines - a new era in vaccinology

Norbert Pardi et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

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Article Immunology

Vaccination in immunocompromised host: Recommendations of Italian Primary Immunodeficiency Network Centers (IPINET)

Baldassarre Martire et al.

VACCINE (2018)

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Article Immunology

The Use of Salmonella Typhim Vaccine to Diagnose Antibody Deficiency

Mary T. Bausch-Jurken et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2017)

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Review Allergy

Influenza Vaccination in Patients with Common Variable Immunodeficiency (CVID)

Jan F. Mieves et al.

CURRENT ALLERGY AND ASTHMA REPORTS (2017)

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Article Immunology

Multicenter study for the evaluation of the antibody response against salmonella typhi Vi vaccination (EMPATHY) for the diagnosis of Anti-polysaccharide antibody production deficiency in patients with primary immunodeficiency

S. Sanchez-Ramon et al.

CLINICAL IMMUNOLOGY (2016)

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Review Allergy

Vaccination in Primary Immunodeficiency Disorders

Ali Sobh et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2016)

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Editorial Material Allergy

International Consensus Document (ICON): Common Variable Immunodeficiency Disorders

Francisco A. Bonilla et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2016)

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Article Allergy

Specific Antibody Deficiencies

Luke A. Wall et al.

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (2015)

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Review Immunology

Vaccination in patients with primary immune deficiency, secondary immune deficiency and autoimmunity with immune regulatory abnormalities

Martha M. Eibl et al.

IMMUNOTHERAPY (2015)

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Article Immunology

2013 IDSA Clinical Practice Guideline for Vaccination of the Immunocompromised Host

Lorry G. Rubin et al.

CLINICAL INFECTIOUS DISEASES (2014)

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Article Allergy

Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts

William T. Shearer et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

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Review Immunology

Vaccine use in primary immunodeficiency disorders

Nicola Principi et al.

VACCINE (2014)

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Article Immunology

Quantification of IgM and IgA Anti-Pneumococcal Capsular Polysaccharides by a New ELISA Assay: a Valuable Diagnostic and Prognostic Tool for Common Variable Immunodeficiency

F. M. Cavaliere et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2013)

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Review Immunology

Primary antibody deficiencies

Anne Durandy et al.

NATURE REVIEWS IMMUNOLOGY (2013)

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Article Allergy

Use and interpretation of diagnostic vaccination in primary immunodeficiency: A working group report of the Basic and Clinical Immunology Interest Section of the American Academy of Allergy, Asthma & Immunology

Jordan S. Orange et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

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Article Immunology

Effectiveness of Immunoglobulin Replacement Therapy on Clinical Outcome in Patients with Primary Antibody Deficiencies: Results from a Multicenter Prospective Cohort Study

Isabella Quinti et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2011)

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Article Immunology

Active vaccination in patients with common variable immunodeficiency (CVID)

S. Goldacker et al.

CLINICAL IMMUNOLOGY (2007)

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Article Immunology

Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency

Isabella Quinti et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2007)

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Article Allergy

The loss of IgM memory B cells correlates with clinical disease in common variable immunodeficiency

R Carsetti et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2005)

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Article Medicine, General & Internal

Failure to clear persistent vaccine-derived neurovirulent poliovirus infection in an immunodeficient man

C MacLennan et al.

LANCET (2004)

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